Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy

Park, Yang-Kyun; Sharp, Gregory C.; Phillips, Justin; Winey, Brian A.

doi:10.1118/1.4923179

Title: Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy

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Abstract

Purpose: To demonstrate the feasibility of proton dose calculation on scatter-corrected cone-beam computed tomographic (CBCT) images for the purpose of adaptive proton therapy. Methods: CBCT projection images were acquired from anthropomorphic phantoms and a prostate patient using an on-board imaging system of an Elekta infinity linear accelerator. Two previously introduced techniques were used to correct the scattered x-rays in the raw projection images: uniform scatter correction (CBCT{sub us}) and a priori CT-based scatter correction (CBCT{sub ap}). CBCT images were reconstructed using a standard FDK algorithm and GPU-based reconstruction toolkit. Soft tissue ROI-based HU shifting was used to improve HU accuracy of the uncorrected CBCT images and CBCT{sub us}, while no HU change was applied to the CBCT{sub ap}. The degree of equivalence of the corrected CBCT images with respect to the reference CT image (CT{sub ref}) was evaluated by using angular profiles of water equivalent path length (WEPL) and passively scattered proton treatment plans. The CBCT{sub ap} was further evaluated in more realistic scenarios such as rectal filling and weight loss to assess the effect of mismatched prior information on the corrected images. Results: The uncorrected CBCT and CBCT{sub us} images demonstrated substantial WEPL discrepancies (7.3 ± 5.3 mm andmore »« less

Authors:

Park, Yang-Kyun; Sharp, Gregory C.; Phillips, Justin; Winey, Brian A. ^[1]

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 (United States)

Publication Date:: Sat Aug 15 00:00:00 EDT 2015

OSTI Identifier:: 22581408

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 42; Journal Issue: 8; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; ALGORITHMS; ANIMAL TISSUES; COMPUTERIZED TOMOGRAPHY; CORRECTIONS; FEASIBILITY STUDIES; IMAGE PROCESSING; LINEAR ACCELERATORS; PROSTATE; PROTON BEAMS; RADIATION DOSES; RADIOTHERAPY

Citation Formats


                    Park, Yang-Kyun, Sharp, Gregory C., Phillips, Justin, and Winey, Brian A. Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy.  United States: N. p., 2015. 
        Web.  doi:10.1118/1.4923179.

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                    Park, Yang-Kyun, Sharp, Gregory C., Phillips, Justin, & Winey, Brian A. Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy.  United States.  https://doi.org/10.1118/1.4923179

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                    Park, Yang-Kyun, Sharp, Gregory C., Phillips, Justin, and Winey, Brian A. 2015.  
        "Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy".  United States.  https://doi.org/10.1118/1.4923179.

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@article{osti_22581408,

  title        = {Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy},

  author       = {Park, Yang-Kyun and Sharp, Gregory C. and Phillips, Justin and Winey, Brian A.},

  abstractNote = {Purpose: To demonstrate the feasibility of proton dose calculation on scatter-corrected cone-beam computed tomographic (CBCT) images for the purpose of adaptive proton therapy. Methods: CBCT projection images were acquired from anthropomorphic phantoms and a prostate patient using an on-board imaging system of an Elekta infinity linear accelerator. Two previously introduced techniques were used to correct the scattered x-rays in the raw projection images: uniform scatter correction (CBCT{sub us}) and a priori CT-based scatter correction (CBCT{sub ap}). CBCT images were reconstructed using a standard FDK algorithm and GPU-based reconstruction toolkit. Soft tissue ROI-based HU shifting was used to improve HU accuracy of the uncorrected CBCT images and CBCT{sub us}, while no HU change was applied to the CBCT{sub ap}. The degree of equivalence of the corrected CBCT images with respect to the reference CT image (CT{sub ref}) was evaluated by using angular profiles of water equivalent path length (WEPL) and passively scattered proton treatment plans. The CBCT{sub ap} was further evaluated in more realistic scenarios such as rectal filling and weight loss to assess the effect of mismatched prior information on the corrected images. Results: The uncorrected CBCT and CBCT{sub us} images demonstrated substantial WEPL discrepancies (7.3 ± 5.3 mm and 11.1 ± 6.6 mm, respectively) with respect to the CT{sub ref}, while the CBCT{sub ap} images showed substantially reduced WEPL errors (2.4 ± 2.0 mm). Similarly, the CBCT{sub ap}-based treatment plans demonstrated a high pass rate (96.0% ± 2.5% in 2 mm/2% criteria) in a 3D gamma analysis. Conclusions: A priori CT-based scatter correction technique was shown to be promising for adaptive proton therapy, as it achieved equivalent proton dose distributions and water equivalent path lengths compared to those of a reference CT in a selection of anthropomorphic phantoms.},

  doi          = {10.1118/1.4923179},

  url          = {https://www.osti.gov/biblio/22581408},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 8,

  volume       = 42,

  place        = {United States},

  year         = {Sat Aug 15 00:00:00 EDT 2015},

  month        = {Sat Aug 15 00:00:00 EDT 2015}

}

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