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Title: Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships

Abstract

While, intramolecular hydrogen bonds have attracted the greatest attention in studies of peptide conformations, the recognition that several other weakly polar interactions may be important determinants of folded structure has been growing. Burley and Petsko provided a comprehensive overview of the importance of weakly polar interactions, in shaping protein structures. The interactions between aromatic rings, which are spatially approximate, have attracted special attention. A survey of the proximal aromatic residue pairs in proteins, allowed Burley and Petsko to suggest that, “phenyl ring centroids are separated by a preferential distance of between 4.5 and 7 Å, and dihedral angles approximately 90° are most common”.

Authors:
;  [1];  [2]
  1. Molecular Biophysics Unit, Indian Institute of Sciences-Bangalore, Karnataka (India)
  2. Bio-Spatial Technology Research Unit, Department of Environmental Biotechnology, School of Environmental Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu (India)
Publication Date:
OSTI Identifier:
22504545
Resource Type:
Journal Article
Journal Name:
Research and Reviews: Journal of Chemistry
Additional Journal Information:
Journal Volume: 5; Journal Issue: 1; Other Information: Copyright: (c) 2016 Rajagopal Appavu; This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 2319-9849
Country of Publication:
India
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; HYDROGEN; INTERACTIONS; PEPTIDES; RESIDUES; STRUCTURE-ACTIVITY RELATIONSHIPS

Citation Formats

Rajagopal, Appavu, Deepa, Mohan, and Govindaraju, Munisamy. Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships. India: N. p., 2016. Web.
Rajagopal, Appavu, Deepa, Mohan, & Govindaraju, Munisamy. Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships. India.
Rajagopal, Appavu, Deepa, Mohan, and Govindaraju, Munisamy. 2016. "Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships". India.
@article{osti_22504545,
title = {Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships},
author = {Rajagopal, Appavu and Deepa, Mohan and Govindaraju, Munisamy},
abstractNote = {While, intramolecular hydrogen bonds have attracted the greatest attention in studies of peptide conformations, the recognition that several other weakly polar interactions may be important determinants of folded structure has been growing. Burley and Petsko provided a comprehensive overview of the importance of weakly polar interactions, in shaping protein structures. The interactions between aromatic rings, which are spatially approximate, have attracted special attention. A survey of the proximal aromatic residue pairs in proteins, allowed Burley and Petsko to suggest that, “phenyl ring centroids are separated by a preferential distance of between 4.5 and 7 Å, and dihedral angles approximately 90° are most common”.},
doi = {},
url = {https://www.osti.gov/biblio/22504545}, journal = {Research and Reviews: Journal of Chemistry},
issn = {2319-9849},
number = 1,
volume = 5,
place = {India},
year = {Fri Feb 26 00:00:00 EST 2016},
month = {Fri Feb 26 00:00:00 EST 2016}
}