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Title: Gain and frequency tuning within the mouse cochlear apex

Normal mammalian hearing requires cochlear outer hair cell active processes that amplify the traveling wave with high gain and sharp tuning, termed cochlear amplification. We have used optical coherence tomography to study cochlear amplification within the apical turn of the mouse cochlea. We measured not only classical basilar membrane vibratory tuning curves but also vibratory responses from the rest of the tissues that compose the organ of Corti. Basilar membrane tuning was sharp in live mice and broad in dead mice, whereas other regions of the organ of Corti demonstrated phase shifts consistent with additional filtering beyond that provided by basilar membrane mechanics. We use these experimental data to support a conceptual framework of how cochlear amplification is tuned within the mouse cochlear apex. We will also study transgenic mice with targeted mutations that affect different biomechanical aspects of the organ of Corti in an effort to localize the underlying processes that produce this additional filtering.
Authors:
;  [1] ;  [1] ;  [2] ;  [1] ;  [2] ;  [3] ;  [4] ;  [5]
  1. Department of Otolaryngology, Stanford University School of Medicine, Stanford, California (United States)
  2. (United States)
  3. Department of Neuroscience, Department of Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas (United States)
  4. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee (United States)
  5. Department of Biomedical Engineering, Texas A&M University, College Station, Texas (United States)
Publication Date:
OSTI Identifier:
22496249
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1703; Journal Issue: 1; Conference: 12. international workshop on the mechanics of hearing, Cape Sounio (Greece), 23-29 Jun 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ANIMAL TISSUES; DIAGRAMS; FILTERS; GAIN; HAIR; MECHANICS; MEMBRANES; MUTATIONS; PHASE SHIFT; PLANT TISSUES; TOMOGRAPHY; TRANSGENIC MICE; TRAVELLING WAVES; TUNING; WAVE PROPAGATION