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Title: Neurohumoral indicators of efficacy radiofrequency cardiac denervation

In this study, we compared pre- and postoperative parameters of the cardiac sympathetic innervation. The aim of the study was to examine the approaches to evaluating the quality of radiofrequency (RF)-induced cardiac denervation by using non-invasive and laboratory methods. The study included 32 people with long-lasting persistent atrial fibrillation (AF). The patients were divided into 2 groups according to the objectives of the study: group 1 (main) - 21 patients with mitral valve diseases, which simultaneously with radiofrequency ablation (RFA) AF carried out on the effects of the paraganglionic nervous plexuses by C. Pappone (2004) and N. Doll (2008) schemes. The second group (control) contained 11 patients with heart diseases in sinus rhythm (the RF denervation not been performed). All patients, who underwent surgical treatment, were received examination of cardiac sympathetic tone by using {sup 123}I-MIBG. All of them made blood analysis from ascending aorta and coronary sinus to determine the level of norepinephrine and its metabolites before and after cardiac denervation. Data of radionuclide examination are correlating with laboratory data.
Authors:
;  [1] ;  [2] ; ; ; ; ; ;  [3] ; ;  [4] ;  [2] ;  [5] ; ; ;  [1] ;  [6] ;
  1. National Research Tomsk State University, Tomsk (Russian Federation)
  2. (Russian Federation)
  3. Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk (Russian Federation)
  4. National Research Tomsk Polytechnic University, Tomsk (Russian Federation)
  5. Academician E.N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk (Russian Federation)
  6. Institute of Strength Physics and Materials Science of the Siberian Branch of the RAS, Tomsk (Russian Federation)
Publication Date:
OSTI Identifier:
22496163
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1688; Journal Issue: 1; Conference: NEWOT'2015: 5. international scientific conference on new operational technologies, Tomsk (Russian Federation), 29-30 Sep 2015; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; AORTA; BLOOD; CARDIOVASCULAR DISEASES; COMPARATIVE EVALUATIONS; CORONARIES; INDICATORS; IODINE 123; METABOLITES; MIBG; NONDESTRUCTIVE ANALYSIS; NORADRENALINE; PATIENTS; RADIOWAVE RADIATION; SURGERY; VALVES