skip to main content

Title: Reparative neurogenesis after cerebral ischemia: Clinical application prospects

At the present time two main approaches are in the focus of neurobiological studies of brain recovery after a stroke. One of them is concerned with the infusion of stem cells in damaged brain. The second approach is directed at the stimulation of endogenous reparative processes, in particular, adult neurogenesis. This review considers alterations of adult neurogenesis caused by cerebral ischemia and possible pathways of its regulation. Multiple studies on animal models have shown that adult neurogenesis is mostly increased by cerebral ischemia. In spite of increasing proliferation and moving neural progenitors to infarct zone, most newborn neurons die before reaching maturity. Besides, an increase of neurogenesis in pathological conditions is mainly due to recruitment of new stem cells, but not due to an additional precursor-cells division that results in an overall decline of the regeneration capacity. Thus, the endogenous reparative mechanisms are not sufficient, and the search for new targets to promote proliferation, survival, and maturation of new neurons after a stroke is needed. Neurotransmitter systems and anti-inflammatory drugs are considered as potential regulators of post-ischemic neurogenesis growth factors.
Authors:
 [1]
  1. Tomsk State University, Research Institute of Biology and Biophysics, Laboratory of Neurobiology (Russian Federation)
Publication Date:
OSTI Identifier:
22496154
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1688; Journal Issue: 1; Conference: NEWOT'2015: 5. international scientific conference on new operational technologies, Tomsk (Russian Federation), 29-30 Sep 2015; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ADULTS; BIOLOGICAL RECOVERY; BRAIN; CELL DIVISION; CELL PROLIFERATION; INFANTS; INFLAMMATION; ISCHEMIA; NEONATES; NERVE CELLS; REGENERATION; STEM CELLS; STIMULATION