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Title: Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial activities

Four chalcones derivatives have been synthesized from 3,4-dimethoxybenzaldehyde and acetophenone derivatives (2-hydroxy acetophenone, 2,4-dihydroxy acetophenone, 2,5-dihydroxy acetophenone and 2,6-dihydroxy acetophenone). The synthesis of these chalcones were conducted by Claisen-Schmidt condensation using grinding techniques at room temperature in the absence of solvents. The chalcones were prepared by grinding together equivalent amount of the approriate hydroxyacetophenone and 3,4-dimethoxybenzaldehyde in the presence of solid sodium hydroxide. Grinding techniques for synthesis of the chalcones derivatives is simple, efficient and environmentally benign compared to conventional methods. Then, the four chalcones derivatives undergo cyclization reactions to produce four flavones after reacted with iodine. The synthesized compounds were characterized by spectrometry (IR, {sup 1}H-NMR, {sup 13}C-NMR and MS)
Authors:
;  [1] ; ;  [2] ;  [3]
  1. Universitas Sebelas Maret, Ir Sutami 36A Surakarta Indonesia, 57126 (Indonesia)
  2. Department of Chemistry FMJPA Universitas Gadjah Mada, Jl Sekip Utara, Yogyakarta Indonesia 55281 (Indonesia)
  3. Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Jl. Sekip Utara Yogyakarta Indonesia, 55281 (Indonesia)
Publication Date:
OSTI Identifier:
22494624
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1710; Journal Issue: 1; Conference: NNS2015: 6. nanoscience and nanotechnology symposium, Surakarta (Indonesia), 4-5 Nov 2015; Other Information: (c) 2016 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACETOPHENONE; CARBON 13; CYCLIZATION; FLAVONES; GRINDING; HYDROGEN 1; IODINE; NUCLEAR MAGNETIC RESONANCE; SODIUM HYDROXIDES; SOLVENTS; SPECTROSCOPY; SYNTHESIS; TEMPERATURE RANGE 0273-0400 K