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Title: Swept source optical coherence tomography for in vivo imaging and vibrometry in the apex of the mouse cochlea

Cochlear amplification has been most commonly investigated by measuring the vibrations of the basilar membrane in animal models. Several different techniques have been used for measuring these vibrations such as laser Doppler vibrometry, miniature pressure sensors, low coherence interferometry, and spectral-domain optical coherence tomography (SD-OCT). We have built a swept-source OCT (SS-OCT) system, which is similar to SD-OCT in that it is capable of performing both imaging and vibration measurements within the mouse cochlea in vivo without having to open the bone. In vivo 3D images of a mouse cochlea were obtained, and the basilar membrane, tectorial membrane, Reissner’s membrane, tunnel of Corti, and reticular lamina could all be resolved. We measured vibrations of multiple structures within the mouse cochlea to sound stimuli. As well, we measured the radial deflections of the reticular lamina and tectorial membrane to estimate the displacement of the outer hair cell stereocilia. These measurements have the potential to more clearly define the mechanisms underlying the linear and non-linear processes within the mammalian cochlea.
Authors:
 [1] ;  [2] ; ;  [3] ;  [1] ;  [4]
  1. E.L. Ginzton Laboratory and Department of Electrical Engineering, Stanford University, Stanford, California (United States)
  2. (United States)
  3. Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California (United States)
  4. Department of Biomedical Engineering, Texas A&M University, College Station, Texas (United States)
Publication Date:
OSTI Identifier:
22494507
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1703; Journal Issue: 1; Conference: 12. international workshop on the mechanics of hearing, Cape Sounio (Greece), 23-29 Jun 2014; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; AMPLIFICATION; BIOMEDICAL RADIOGRAPHY; HAIR; IMAGES; IN VIVO; INTERFEROMETRY; LASERS; MEMBRANES; MICE; NONLINEAR PROBLEMS; SENSORS; SOUND WAVES; STIMULI; TOMOGRAPHY