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Title: Exploring the stochastic dynamics of correlated movement of receptor proteins in plasma membranes in vivo

Ligand-induced receptor dimerization plays a crucial role in the signaling process of living cells. In this study, we developed a theoretical model and performed single-molecule tracking to explore the correlated diffusion processes of liganded epidermal growth factor receptors prior to dimer formation. We disclosed that both an attractive potential between liganded receptor proteins in proximity and correlated fluctuations in the local environments of the proteins play an important role to produce the observed correlated movement of the receptors. This result can serve as the foundation to shed light on the way in which receptor functions are regulated in plasma membranes in vivo.
Authors:
 [1] ;  [2]
  1. The T.K.B. Research Center of Photonics, Chiao Tung University, Hsinchu 300, Taiwan (China)
  2. Department of Photonics, Chiao Tung University, Hsinchu 300, Taiwan (China)
Publication Date:
OSTI Identifier:
22493332
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Chemical Physics; Journal Volume: 143; Journal Issue: 22; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; DIFFUSION; DIMERIZATION; DIMERS; FLUCTUATIONS; GROWTH FACTORS; IN VIVO; LIGANDS; MEMBRANES; MOLECULES; POTENTIALS; RECEPTORS; STOCHASTIC PROCESSES; VISIBLE RADIATION