Exploring the stochastic dynamics of correlated movement of receptor proteins in plasma membranes in vivo

Journal Article · Mon Dec 14 00:00:00 EST 2015 · Journal of Chemical Physics

DOI:https://doi.org/10.1063/1.4936963· OSTI ID:22493332

Lin, Chien Y. ^[1]

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1. Department of Photonics, Chiao Tung University, Hsinchu 300, Taiwan (China)

Ligand-induced receptor dimerization plays a crucial role in the signaling process of living cells. In this study, we developed a theoretical model and performed single-molecule tracking to explore the correlated diffusion processes of liganded epidermal growth factor receptors prior to dimer formation. We disclosed that both an attractive potential between liganded receptor proteins in proximity and correlated fluctuations in the local environments of the proteins play an important role to produce the observed correlated movement of the receptors. This result can serve as the foundation to shed light on the way in which receptor functions are regulated in plasma membranes in vivo.

• OSTI ID: 22493332
• Journal Information: Journal of Chemical Physics, Vol. 143, Issue 22; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-9606
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
DIFFUSION
DIMERIZATION
DIMERS
FLUCTUATIONS
GROWTH FACTORS
IN VIVO
LIGANDS
MEMBRANES
MOLECULES
POTENTIALS
RECEPTORS
STOCHASTIC PROCESSES
VISIBLE RADIATION