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Title: Cumulative phase delay imaging - A new contrast enhanced ultrasound modality

Recently, a new acoustic marker for ultrasound contrast agents (UCAs) has been introduced. A cumulative phase delay (CPD) between the second harmonic and fundamental pressure wave field components is in fact observable for ultrasound propagating through UCAs. This phenomenon is absent in the case of tissue nonlinearity and is dependent on insonating pressure and frequency, UCA concentration, and propagation path length through UCAs. In this paper, ultrasound images based on this marker are presented. The ULA-OP research platform, in combination with a LA332 linear array probe (Esaote, Firenze Italy), were used to image a gelatin phantom containing a PVC plate (used as a reflector) and a cylindrical cavity measuring 7 mm in diameter (placed in between the observation point and the PVC plate). The cavity contained a 240 µL/L SonoVueO{sup ®} UCA concentration. Two insonating frequencies (3 MHz and 2.5 MHz) were used to scan the gelatine phantom. A mechanical index MI = 0.07, measured in water at the cavity location with a HGL-0400 hydrophone (Onda, Sunnyvale, CA), was utilized. Processing the ultrasound signals backscattered from the plate, ultrasound images were generated in a tomographic fashion using the filtered back-projection method. As already observed in previous studies, significantly higher CPD values are measured whenmore » imaging at a frequency of 2.5 MHz, as compared to imaging at 3 MHz. In conclusion, these results confirm the applicability of the discussed CPD as a marker for contrast imaging. Comparison with standard contrast-enhanced ultrasound imaging modalities will be the focus of future work.« less
Authors:
; ;  [1] ;  [1] ;  [2]
  1. Lab. of Biomedical Diagnostics, Dept. of Electrical Eng., Eindhoven University of Technology (Netherlands)
  2. (Netherlands)
Publication Date:
OSTI Identifier:
22492636
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1685; Journal Issue: 1; Conference: 20. international symposium on nonlinear acoustics, Ecully (France), 29 Jun - 3 Jul 2015, 2. international sonic boom forum, Ecully (France), 29 Jun - 3 Jul 2015; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ANIMAL TISSUES; BACKSCATTERING; BIOMEDICAL RADIOGRAPHY; CAVITIES; COMPARATIVE EVALUATIONS; CONCENTRATION RATIO; CONTRAST MEDIA; CYLINDRICAL CONFIGURATION; FILTERS; GELATIN; IMAGES; MHZ RANGE 01-100; NONLINEAR PROBLEMS; PHANTOMS; SIGNALS; ULTRASONIC WAVES; ULTRASONOGRAPHY; WATER