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Title: Preparation and features of polycaprolactone vascular grafts with the incorporated vascular endothelial growth factor

The development of tissue-engineered small-diameter vascular grafts is an urgent issue in cardiovascular surgery. In this study, we assessed how the incorporation of the vascular endothelial growth factor (VEGF) affects morphological and mechanical properties of polycaprolactone (PCL) vascular grafts along with its release kinetics. Vascular grafts were prepared using two-phase electrospinning. In pursuing our aims, we performed scanning electron microscopy, mechanical testing, and enzyme-linked immunosorbent assay. Our results demonstrated the preservation of a highly porous structure and improvement of PCL/VEGF scaffold mechanical properties as compared to PCL grafts. A prolonged VEGF release testifies the use of this construct as a scaffold for tissue-engineered vascular grafts.
Authors:
; ; ; ; ; ;  [1]
  1. Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (Russian Federation)
Publication Date:
OSTI Identifier:
22492589
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1683; Journal Issue: 1; Conference: International conference on advanced materials with hierarchical structure for new technologies and reliable structures 2015, Tomsk (Russian Federation), 21-25 Sep 2015; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CARDIOVASCULAR SYSTEM; COMPARATIVE EVALUATIONS; ENZYMES; GRAFTS; GROWTH FACTORS; LACTONES; MECHANICAL PROPERTIES; POROUS MATERIALS; SCANNING ELECTRON MICROSCOPY; SURGERY