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Title: Thermal infrared images to quantify thermal ablation effects of acid and base on target tissues

Hyperthermia (42-46°C), treatment of tumor tissue through elevated temperature, offers several advantages including high cost-effectiveness, highly targeted ablation and fewer side effects and hence higher safety level over traditional therapies such as chemotherapy and radiotherapy. Recently, hyperthermia using heat release through exothermic acid-base neutralization comes into view owing to its relatively safe products of salt and water and highly confined ablation. However, lack of quantitative understanding of the spatial and temporal temperature profiles that are produced by simultaneous diffusion of liquid chemical and its chemical reaction within tumor tissue impedes the application of this method. This article is dedicated to quantify thermal ablation effects of acid and base both individually and as in neutralization via infrared captured thermal images. A theoretical model is used to approximate specific heat absorption rate (SAR) based on experimental measurements that contrast two types of tissue, normal pork and pig liver. According to the computation, both pork and liver tissue has a higher ability in absorbing hydrochloric acid (HCl) than sodium hydroxide, hence suggesting that a reduced dosage for HCl is appropriate in a surgery. The heating effect depends heavily on the properties of tissue types and amount of chemical reagents administered. Given thermal parametersmore » such as SAR for different tissues, a computational model can be made in predicting temperature transitions which will be helpful in planning and optimizing surgical hyperthermia procedures.« less
Authors:
;  [1] ;  [2]
  1. Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084 (China)
  2. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 (United States)
Publication Date:
OSTI Identifier:
22492274
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Advances; Journal Volume: 5; Journal Issue: 7; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ABLATION; ABSORPTION; ANIMAL TISSUES; CHEMICAL REACTIONS; CHEMOTHERAPY; DIFFUSION; HEATING; HYDROCHLORIC ACID; HYPERTHERMIA; IMAGES; LIVER; NEOPLASMS; RADIOTHERAPY; REAGENTS; SALTS; SIDE EFFECTS; SODIUM HYDROXIDES; SPECIFIC HEAT; SURGERY; TRANSITION TEMPERATURE