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Title: Evaluation of the effects of a plasma activated medium on cancer cells

The interaction of low temperature plasma with liquids is a relevant topic of study to the field of plasma medicine. This is because cells and tissues are normally surrounded or covered by biological fluids. Therefore, the chemistry induced by the plasma in the aqueous state becomes crucial and usually dictates the biological outcomes. This process became even more important after the discovery that plasma activated media can be useful in killing various cancer cell lines. Here, we report on the measurements of concentrations of hydrogen peroxide, a species known to have strong biological effects, produced by application of plasma to a minimum essential culture medium. The activated medium is then used to treat SCaBER cancer cells. Results indicate that the plasma activated medium can kill the cancer cells in a dose dependent manner, retain its killing effect for several hours, and is as effective as apoptosis inducing drugs.
Authors:
; ; ; ;  [1]
  1. Plasma Engineering and Medicine Institute, Old Dominion University, Norfolk, Virginia 23529 (United States)
Publication Date:
OSTI Identifier:
22489901
Resource Type:
Journal Article
Resource Relation:
Journal Name: Physics of Plasmas; Journal Volume: 22; Journal Issue: 12; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; APOPTOSIS; BIOLOGICAL EFFECTS; BODY FLUIDS; COLD PLASMA; CONCENTRATION RATIO; CULTURE MEDIA; DRUGS; HYDROGEN PEROXIDE; MEDICINE; NEOPLASMS