skip to main content

Title: Composite vascular repair grafts via micro-imprinting and electrospinning

Composite vascular grafts formed by micro-imprinting and electrospinning exhibited improved mechanical properties relative to those formed by electrospinning alone. The three-layered composite grafts mimic the three-layered structure of natural blood vessels. The middle layer is made by micro-imprinting poly-p-dioxanone (PPDO), while the inner and outer layers are electrospun mixtures of chitosan and polyvinyl alcohol. The graft morphology is characterized with scanning electron microscopy. For constant graft thicknesses, the PPDO increases the mechanical strength. Cells cultivated on the vascular grafts adhere and proliferate better because of the natural, biological chitosan in the inner and outer layers. Overall, the composite scaffolds could be good candidates for blood vessel repair.
Authors:
;  [1] ;  [2] ; ; ;  [1]
  1. Rapid Manufacturing Engineering Center, Shanghai University, Shanghai 200444 (China)
  2. (China)
Publication Date:
OSTI Identifier:
22488518
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Advances; Journal Volume: 5; Journal Issue: 4; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; AMINO ACIDS; BLOOD VESSELS; MECHANICAL PROPERTIES; MIXTURES; OLIGOSACCHARIDES; PVA; SCANNING ELECTRON MICROSCOPY