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Title: SU-C-204-04: Patient Specific Proton Stopping Powers Estimation by Combining Proton Radiography and Prior-Knowledge X-Ray CT Information

Purpose: The material relative stopping power (RSP) uncertainty is the highest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate, patient specific, RSP by combining 1) pre-treatment x-ray CT and 2) daily proton radiograph of the patient. Methods: The method is formulated as a linear least-square optimization problem (min||Ax-B||2). The parameter A represents the pathlength crossed by the proton in each material. The RSPs for the materials (water equivalent thickness (WET)/physical thickness) are denoted by x. B is the proton radiograph expressed as WET crossed. The problem is minimized using a convex-conic optimization algorithm with xi
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8]
  1. Massachussetts General Hospital, Quebec, Quebec (Canada)
  2. (Belgium)
  3. (Denmark)
  4. (Canada)
  5. Ion Beam Application, Louvain-la-neuve (Belgium)
  6. Aarhus University, Aarhus, Aarhus (Denmark)
  7. Centre Hospitalier Univ de Quebec, Quebec, QC (Canada)
  8. Mass General Hospital, Harvard Medical, Boston, MA (United States)
Publication Date:
OSTI Identifier:
22486569
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; COMPUTERIZED TOMOGRAPHY; ENERGY LOSSES; LEAST SQUARE FIT; LUNGS; OPTIMIZATION; PATIENTS; PHANTOMS; PROTON BEAMS; PROTON RADIOGRAPHY; RADIOTHERAPY; STOPPING POWER; THICKNESS