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Title: Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging

We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T{sub 2}) was observed for aqueous suspensions of PSi NPs, whereas the longitudinal relaxation time (T{sub 1}) changed moderately. The longitudinal and transversal relaxivities are estimated to be 0.03 and 0.4 l/(g·s), respectively, which are promising for biomedical studies. The proton relaxation is suggested to undergo via the magnetic dipole-dipole interaction with Si dangling bonds on surfaces of PSi NPs. MRI experiments with phantoms have revealed the remarkable contrasting properties of PSi NPs for medical diagnostics.
Authors:
; ;  [1] ;  [2] ; ;  [3] ;  [4] ;  [1] ;  [1] ;  [2] ;  [1] ;  [2]
  1. Department of Physics, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
  2. (Russian Federation)
  3. Moscow Institute of Physics and Technology, Dolgoprudny, 141700 Moscow Region (Russian Federation)
  4. Research Center for MRI and MRS, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
Publication Date:
OSTI Identifier:
22486214
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 107; Journal Issue: 23; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CONTRAST MEDIA; MAGNETIC DIPOLES; NANOPARTICLES; NMR IMAGING; PHANTOMS; POROUS MATERIALS; PROTONS; RELAXATION TIME; SILICON; SUSPENSIONS