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Title: Combined Néel and Brown rotational Langevin dynamics in magnetic particle imaging, sensing, and therapy

Magnetic nanoparticles have been studied intensely because of their possible uses in biomedical applications. Biosensing using the rotational freedom of particles has been used to detect biomarkers for cancer, hyperthermia therapy has been used to treat tumors, and magnetic particle imaging is a promising new imaging modality that can spatially resolve the concentration of nanoparticles. There are two mechanisms by which the magnetization of a nanoparticle can rotate, a fact that poses a challenge for applications that rely on precisely one mechanism. The challenge is exacerbated by the high sensitivity of the dominant mechanism to applied fields. Here, we demonstrate stochastic Langevin equation simulations for the combined rotation in magnetic nanoparticles exposed to oscillating applied fields typical to these applications to both highlight the existing relevant theory and quantify which mechanism should occur in various parameter ranges.
Authors:
 [1] ;  [1] ;  [2]
  1. Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States)
  2. (United States)
Publication Date:
OSTI Identifier:
22486166
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 107; Journal Issue: 22; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; BIOLOGICAL MARKERS; CONCENTRATION RATIO; HYPERTHERMIA; LANGEVIN EQUATION; MAGNETIZATION; NANOPARTICLES; NEOPLASMS; SENSITIVITY; SIMULATION; THERAPY