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Title: Electronic transport in methylated fragments of DNA

We investigate the electronic transport properties of methylated deoxyribonucleic-acid (DNA) strands, a biological system in which methyl groups are added to DNA (a major epigenetic modification in gene expression), sandwiched between two metallic platinum electrodes. Our theoretical simulations apply an effective Hamiltonian based on a tight-binding model to obtain current-voltage curves related to the non-methylated/methylated DNA strands. The results suggest potential applications in the development of novel biosensors for molecular diagnostics.
Authors:
; ; ; ; ;  [1] ;  [2] ;  [3] ; ;  [4]
  1. Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, 59072-970 Natal-RN (Brazil)
  2. Departamento de Física, Universidade Federal do Ceará, 60455-760 Fortaleza, CE (Brazil)
  3. Instituto Federal de Educação, Ciência e Tecnologia do Ceará, 60040-531 Fortaleza, CE (Brazil)
  4. Instituto de Física, Universidade Federal de Alagoas, 57072-900 Maceió-AL (Brazil)
Publication Date:
OSTI Identifier:
22486107
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 107; Journal Issue: 20; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; DNA; ELECTRIC CONDUCTIVITY; ELECTRODES; GENES; HAMILTONIANS; MODIFICATIONS; PLATINUM; SIMULATION