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Title: An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry

In this work, laser-based wavelength-modulated differential photothermal radiometry (WM-DPTR) is applied to develop a non-invasive in-vehicle alcohol biosensor. WM-DPTR features unprecedented ethanol-specificity and sensitivity by suppressing baseline variations through a differential measurement near the peak and baseline of the mid-infrared ethanol absorption spectrum. Biosensor signal calibration curves are obtained from WM-DPTR theory and from measurements in human blood serum and ethanol solutions diffused from skin. The results demonstrate that the WM-DPTR-based calibrated alcohol biosensor can achieve high precision and accuracy for the ethanol concentration range of 0-100 mg/dl. The high-performance alcohol biosensor can be incorporated into ignition interlocks that could be fitted as a universal accessory in vehicles in an effort to reduce incidents of drinking and driving.
Authors:
;  [1] ;  [2] ;  [1]
  1. Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, Toronto, Ontario M5S 3G8 (Canada)
  2. (Canada)
Publication Date:
OSTI Identifier:
22482613
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 86; Journal Issue: 11; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ABSORPTION SPECTRA; ACCURACY; BLOOD SERUM; CALIBRATION; DIAGRAMS; ETHANOL; SKIN; SOLUTIONS