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Title: Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurementsmore » of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.« less
Authors:
; ;  [1] ; ; ;  [2] ; ;  [3] ;  [4]
  1. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
  2. Ion Beam Applications SA, Louvain-la-Neuve 1348 (Belgium)
  3. School of Biomedical Engineering, Drexel University, Philadelphia, Pennsylvania 19104 (United States)
  4. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
Publication Date:
OSTI Identifier:
22482436
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 12; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACOUSTIC MEASUREMENTS; AMPLITUDES; ENERGY ABSORPTION; ENERGY LOSSES; FUNCTION GENERATORS; HOSPITALS; IN VIVO; ISOCHRONOUS CYCLOTRONS; PATIENTS; PRESSURE RANGE MEGA PA; PROTON BEAMS; SOUND WAVES; VERIFICATION