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Title: Desynchronization of stochastically synchronized chemical oscillators

Experimental and theoretical studies are presented on the design of perturbations that enhance desynchronization in populations of oscillators that are synchronized by periodic entrainment. A phase reduction approach is used to determine optimal perturbation timing based upon experimentally measured phase response curves. The effectiveness of the perturbation waveforms is tested experimentally in populations of periodically and stochastically synchronized chemical oscillators. The relevance of the approach to therapeutic methods for disrupting phase coherence in groups of stochastically synchronized neuronal oscillators is discussed.
Authors:
; ; ;  [1] ; ;  [2] ;  [3]
  1. C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045 (United States)
  2. Department of Mechanical Engineering, University of California, Santa Barbara, California 93106 (United States)
  3. Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455 (United States)
Publication Date:
OSTI Identifier:
22482301
Resource Type:
Journal Article
Resource Relation:
Journal Name: Chaos (Woodbury, N. Y.); Journal Volume: 25; Journal Issue: 12; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; DESIGN; DIAGRAMS; ENTRAINMENT; OSCILLATORS; PERIODICITY; PERTURBATION THEORY; STOCHASTIC PROCESSES; WAVE FORMS