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Title: Lowering of the cavitation threshold in aqueous suspensions of porous silicon nanoparticles for sonodynamic therapy applications

A significant decrease of the cavitation threshold in aqueous suspensions of porous silicon nanoparticles (PSi NPs) with sizes about 100 nm as compared with pure water was observed for ultrasound irradiation (USI) with therapeutic frequency (0.88 MHz) and intensities (about 1 W/cm{sup 2}). This effect is explained by porous morphology of PSi NPs, which promotes the nucleation of cavitation bubbles. In vitro experiments revealed a suppression of the proliferation of cancer cells with the introduced PSi NPs after exposure to USI related to the enhanced cavitation processes, which led to the cell destruction. The obtained results demonstrate that PSi NPs are prospective for applications as sonosensitizers in mild cancer therapy.
Authors:
;  [1] ;  [2] ;  [3] ;  [1] ;  [4] ;  [1] ;  [4]
  1. Faculty of Physics, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
  2. Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow (Russian Federation)
  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, 142290 Pushino, Moscow Region (Russian Federation)
  4. (Russian Federation)
Publication Date:
OSTI Identifier:
22482143
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 107; Journal Issue: 12; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAVITATION; IRRADIATION; MORPHOLOGY; NANOPARTICLES; NEOPLASMS; NUCLEATION; POROUS MATERIALS; SILICON; SUSPENSIONS; THERAPY