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Title: Novel porous graphene oxide and hydroxyapatite nanosheets-reinforced sodium alginate hybrid nanocomposites for medical applications

Graphene oxide (GO) and hydroxyapatite (HAp) are frequently used as reinforcements in polymers to improve mechanical and biological properties. In this work, novel porous hybrid nanocomposites consisting of GO, HAp, and sodium alginate (SA) have been prepared by facile solution mixing and freeze drying in an attempt to obtain a scaffold with desirable mechanical and biological properties. The as-prepared porous GO/HAp/SA hybrid nanocomposites were characterized by SEM, XRD, FTIR, TGA, and mechanical testing. In addition, preliminary cell behavior was assessed by CCK8 assay. It is found that the GO/HAp/SA nanocomposites show improved compressive strength and modulus over neat SA and HAp/SA nanocomposites. CCK8 results reveal that the GO/HAp/SA nanocomposites show enhanced cell proliferation over neat SA and GO/SA nanocomposite. It has been demonstrated that GO/HAp20/SA holds promise in bone tissue engineering. - Graphical abstract: Display Omitted - Highlights: • Graphene oxide (GO), hydroxyapatite (HAp), and alginate (SA) nanocomposites were fabricated. • The novel porous composites were prepared by solution mixture and freeze drying. • The GO/HAp/SA had porous structure with porosity > 85% and pore size > 150 μm. • The GO/HAp/SA exhibited improved mechanical properties over HAp/SA counterparts. • The GO/HAp/SA showed enhanced cell proliferation over GO/SA counterparts.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [2] ;  [3]
  1. School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang 330013 (China)
  2. Research Institute of Biomaterials and Transportation, East China Jiaotong University, Nanchang 330013 (China)
  3. (China)
  4. Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, Hebei United University, Tangshan 063009 (China)
  5. Department of Joint Surgery, Tianjin Hospital, Tianjin 300211 (China)
Publication Date:
OSTI Identifier:
22476180
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Characterization; Journal Volume: 107; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; CELL PROLIFERATION; FOURIER TRANSFORMATION; GRAPHENE; INFRARED SPECTRA; LYOPHILIZATION; NANOCOMPOSITES; NANOSTRUCTURES; OXIDES; POLYMERS; POROSITY; POROUS MATERIALS; SCANNING ELECTRON MICROSCOPY; SODIUM; THERMAL GRAVIMETRIC ANALYSIS; X-RAY DIFFRACTION