PVA and PEG functionalised LSMO nanoparticles for magnetic fluid hyperthermia application

Journal Article · Wed Apr 15 00:00:00 EDT 2015 · Materials Characterization

DOI:https://doi.org/10.1016/J.MATCHAR.2015.03.001· OSTI ID:22476080

Jadhav, S. V.; Nikam, D. S.; Khot, V. M. ^[1]; Mali, S. S.; Hong, C. K. ^[2]

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1. Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur 416006, MS India (India)
2. Polymer Energy Materials Laboratory, Chonnam National University, Gwangju (Korea, Republic of)

La{sub 0.7}Sr{sub 0.3}MnO{sub 3} magnetic nanoparticles are synthesized by a solution combustion method and functionalised with polyvinyl alcohol and polyethylene glycol. The induction heating characteristics of coated magnetic nanoparticles (42 °C) were observed at a reasonably low concentration (5 mg/mL). Remarkably, coated magnetic nanoparticles exhibited a promisingly high specific absorption rate with varying magnetic field and constant frequency. The surface analysis is carried out by X-ray photoelectron spectroscopy. A reduction in the agglomeration of the particles was observed when the magnetic nanoparticles were functionalised with polyvinyl alcohol or polyethylene glycol and can be confirmed by transmission electron microscopy and dynamic light scattering studies. Vibrating sample magnetometer measurements indicate superparamagnetic behaviour at room temperature before and after coating. Colloidal stability revealed a considerably higher zeta potential value for coated system. In vitro cytotoxicity test of the magnetic nanoparticles indicates that coated nanoparticles have no significant effect on cell viability within the tested concentrations (1–5 mg mL{sup -1}) as compared to uncoated La{sub 0.7}Sr{sub 0.3}MnO{sub 3}. All these findings explore the potentiality of La{sub 0.7}Sr{sub 0.3}MnO{sub 3} nanoparticles for magnetic fluid hyperthermia. - Highlights: • Surface functionalization of LSMO nanoparticles — first time with PVA • Surface functionalization of LSMO nanoparticles — first time with PEG • BSA protein — first time used as dispersion medium for stability of LSMO nanoparticles • The heating ability observed at low concentration • Improved efficiency of magnetic fluid hyperthermia treatment with surfactants.

• OSTI ID: 22476080
• Journal Information: Materials Characterization, Vol. 102; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 1044-5803
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
ABSORPTION
LANTHANUM COMPOUNDS
LIGHT SCATTERING
MAGNETIC FIELDS
MOLYBDATES
NANOPARTICLES
POLYETHYLENE GLYCOLS
PVA
REDUCTION
STABILITY
STRONTIUM COMPOUNDS
SUPERPARAMAGNETISM
SURFACES
SURFACTANTS
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY PHOTOELECTRON SPECTROSCOPY