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Title: Interactions between N-acetyl-L-cysteine protected CdTe quantum dots and doxorubicin through spectroscopic method

Highlights: • CdTe quantum dots with the diameter of 3–5 nm were synthesized in aqueous solution. • The modified CdTe quantum dots showed well fluorescence properties. • The interaction between the CdTe quantum dots and doxorubicin (DR) was investigated. - Abstract: N-acetyl-L-cysteine protected cadmium telluride quantum dots with a diameter of 3–5 nm were synthesized in aqueous solution. The interaction between N-acetyl-L-cysteine/cadmium telluride quantum dots and doxorubicin was investigated by ultraviolet–visible absorption and fluorescence spectroscopy at physiological conditions (pH 7.2, 37 °C). The results indicate that electron transfer has occurred between N-acetyl-L-cysteine/cadmium telluride quantum dots and doxorubicin under light illumination. The quantum dots react readily with doxorubicin to form a N-acetyl-L-cysteine/cadmium telluride-quantum dots/doxorubicin complex via electrostatic attraction between the −NH{sub 3}{sup +} moiety of doxorubicin and the −COO{sup −} moiety of N-acetyl-L-cysteine/cadmium telluride quantum dots. The interaction of N-acetyl-L-cysteine/cadmium telluride-quantum dots/doxorubicin complex with bovine serum albumin was studied as well, showing that the complex might induce the conformation change of bovine serum due to changes in microenvironment of bovine serum.
Authors:
 [1] ;  [2] ; ; ; ;  [3]
  1. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Nanchong 637000 (China)
  2. (China)
  3. College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637000 (China)
Publication Date:
OSTI Identifier:
22475801
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Research Bulletin; Journal Volume: 66; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ABSORPTION; AQUEOUS SOLUTIONS; CADMIUM TELLURIDES; CYSTEINE; DOXORUBICIN; ELECTRON TRANSFER; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; ILLUMINANCE; INTERACTIONS; OPTICAL PROPERTIES; PH VALUE; QUANTUM DOTS; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET RADIATION; VISIBLE RADIATION