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Title: Perfusion Angiography of the Foot in Patients with Critical Limb Ischemia: Description of the Technique

Abstract

ObjectiveTo study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI).Methods/ResultsPerfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds.DiscussionThe original angiography data can be used to make a time–density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients.

Authors:
;  [1]
  1. Academic Medical Center, Department of Surgery (Netherlands)
Publication Date:
OSTI Identifier:
22470120
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 38; Journal Issue: 1; Conference: IROS 2015: Interventional Radiological Olbert Symposium, Berlin (Germany), 15-17 Jan 2015; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BIOMEDICAL RADIOGRAPHY; CONTRAST MEDIA; DENSITY; FEET; ISCHEMIA; MOLECULAR WEIGHT; PATIENTS

Citation Formats

Jens, Sjoerd, Marquering, Henk A., E-mail: h.a.marquering@amc.uva.nl, Koelemay, Mark J. W.,, and Reekers, Jim A., E-mail: j.a.reekers@amc.uva.nl. Perfusion Angiography of the Foot in Patients with Critical Limb Ischemia: Description of the Technique. United States: N. p., 2015. Web. doi:10.1007/S00270-014-1036-5.
Jens, Sjoerd, Marquering, Henk A., E-mail: h.a.marquering@amc.uva.nl, Koelemay, Mark J. W.,, & Reekers, Jim A., E-mail: j.a.reekers@amc.uva.nl. Perfusion Angiography of the Foot in Patients with Critical Limb Ischemia: Description of the Technique. United States. https://doi.org/10.1007/S00270-014-1036-5
Jens, Sjoerd, Marquering, Henk A., E-mail: h.a.marquering@amc.uva.nl, Koelemay, Mark J. W.,, and Reekers, Jim A., E-mail: j.a.reekers@amc.uva.nl. 2015. "Perfusion Angiography of the Foot in Patients with Critical Limb Ischemia: Description of the Technique". United States. https://doi.org/10.1007/S00270-014-1036-5.
@article{osti_22470120,
title = {Perfusion Angiography of the Foot in Patients with Critical Limb Ischemia: Description of the Technique},
author = {Jens, Sjoerd and Marquering, Henk A., E-mail: h.a.marquering@amc.uva.nl and Koelemay, Mark J. W., and Reekers, Jim A., E-mail: j.a.reekers@amc.uva.nl},
abstractNote = {ObjectiveTo study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI).Methods/ResultsPerfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds.DiscussionThe original angiography data can be used to make a time–density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients.},
doi = {10.1007/S00270-014-1036-5},
url = {https://www.osti.gov/biblio/22470120}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 1,
volume = 38,
place = {United States},
year = {Sun Feb 15 00:00:00 EST 2015},
month = {Sun Feb 15 00:00:00 EST 2015}
}