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Title: Regional Radiation Pneumonitis After SIRT of a Subcapsular Liver Metastasis: What is the Effect of Direct Beta Irradiation?

We herein present a patient undergoing selective internal radiation therapy with an almost normal lung shunt fraction of 11.5 %, developing histologically proven radiation pneumonitis. Due to a predominance of pulmonary consolidations in the right lower lung and its proximity to a large liver metastases located in the dome of the right liver lobe a Monte Carlo simulation was performed to estimate the effect of direct irradiation of the lung parenchyma. According to our calculations direct irradiation seems negligible and RP is almost exclusively due to ectopic draining of radioactive spheres.
Authors:
 [1] ; ;  [2] ;  [1] ;  [3] ;  [1]
  1. University of Bern, Department of Interventional, Pediatric and Diagnostic Radiology, Inselspital, University Hospital (Switzerland)
  2. University of Bern, Department of Nuclear Medicine, Inselspital, University Hospital (Switzerland)
  3. University of Bern, Institute of Pathology, University Hospital (Switzerland)
Publication Date:
OSTI Identifier:
22469883
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 38; Journal Issue: 4; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BYPASSES; COMPUTERIZED SIMULATION; IRRADIATION; LIVER; LUNGS; METASTASES; MONTE CARLO METHOD; PATIENTS; PNEUMONITIS; RADIOTHERAPY