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Title: Evaluation of Liver Stiffness After Radioembolization by Real-Time ShearWave™ Elastography: Preliminary Study

PurposeTo evaluate the effect of ShearWave™ elastography (SWE) for the assessment of liver fibrosis after radioembolization (RE) in patients with liver malignancies.Materials and MethodsWe prospectively examined the effects of SWE before and after RE in 17 adult patients, from June 2012 to September 2013. All patients underwent SWE within 1 month before and 3 months (96.3 ± 22.9 days) after RE. Measurements were taken in segments III, IV, V, and VI (lateral/medial left lobe and anterior/posterior right lobe, respectively). Liver stiffness was studied in the 39 treated segments.ResultsThe mean stiffness of liver tissue according to the pre-RE SWE measurements was not different from the post-RE SWE measurements in the segments that did not undergo RE. Conversely, segments treated with RE were significantly stiffer according to the post-RE SWE measurements (mean SWE 17.4 kPa) than according to the baseline measurements (7.0 kPa) (p < 0.001). Patients with hepatocellular carcinoma and preexisting infection with hepatitis B and C viruses had higher pre-embolization stiffness, and the post-embolization stiffness of the treated segments in these patients was higher than that in the remainder of the study population.ConclusionThese data suggest that SWE measurements of liver stiffness increase as early as the third month after RE. SWE could be used as a noninvasive complementary imagingmore » method for preliminary assessment of liver fibrosis before and after RE.« less
Authors:
 [1] ;  [2] ; ;  [1] ;  [3] ;  [2] ;  [1]
  1. Istanbul University, Department of Interventional Radiology, Cerrahpasa Faculty of Medicine (Turkey)
  2. Istanbul University, Department of Radiology, Cerrahpasa Faculty of Medicine (Turkey)
  3. Istanbul University, Department of Nuclear Medicine, Cerrahpasa Faculty of Medicine (Turkey)
Publication Date:
OSTI Identifier:
22469880
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 38; Journal Issue: 4; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL TISSUES; BIOMEDICAL RADIOGRAPHY; EVALUATION; FIBROSIS; FLEXIBILITY; HEPATITIS; HEPATOMAS; LIVER; MATERIALS; PATIENTS; PLANT TISSUES; POPULATIONS; RADIOEMBOLIZATION; VASCULAR DISEASES; VIRUSES