Safety of Radioembolization with {sup 90}Yttrium Resin Microspheres Depending on Coiling or No-Coiling of Aberrant/High-Risk Vessels

Journal Article · Sat Aug 15 00:00:00 EDT 2015 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-015-1128-X· OSTI ID:22469857

Paprottka, P. M., E-mail: [e-mail], E-mail: [e-mail]; Paprottka, K. J., E-mail: [e-mail]; Walter, A., E-mail: [e-mail] ^[1]; Haug, A. R., E-mail: [e-mail] ^[2]; Trumm, C. G., E-mail: [e-mail] ^[1]; Lehner, S., E-mail: [e-mail]; Fendler, W. P., E-mail: [e-mail] ^[2]; Jakobs, T. F., E-mail: [e-mail] ^[3]; Reiser, M. F., E-mail: [e-mail] ^[1]; Zech, C. J., E-mail: [e-mail] ^[4]

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1. LMU - University of Munich, Department of Clinical Radiology (Germany)
2. LMU - University of Munich, Department of Nuclear Medicine (Germany)
3. Barmherzige Brueder Munich, Department of Clinical Radiology (Germany)
4. University Hospital Basel, Clinic of Radiology and Nuclear Medicine, Section Interventional Radiology (Switzerland)

PurposeTo evaluate the safety of radioembolization (RE) with {sup 90}Yttrium ({sup 90}Y) resin microspheres depending on coiling or no-coiling of aberrant/high-risk vessels.Materials and MethodsEarly and late toxicity after 566 RE procedures were analyzed retrospectively in accordance with the National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE v3.0). For optimal safety, aberrant vessels were either coil embolized (n = 240/566, coiling group) or a more peripheral position of the catheter tip was chosen to treat right or left liver lobes (n = 326/566, no-coiling group).ResultsClinically relevant late toxicities (≥Grade 3) were observed in 1 % of our overall cohort. The no-coiling group had significantly less “any” (P = 0.0001) or “clinically relevant” (P = 0.0003) early toxicity. There was no significant difference (P > 0.05) in delayed toxicity in the coiling versus the no-coiling group. No RE-induced liver disease was noted after all 566 procedures.ConclusionRE with {sup 90}Y resin microspheres is a safe and effective treatment option. Performing RE without coil embolization of aberrant vessels prior to treatment could be an alternative for experienced centers.

• OSTI ID: 22469857
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 38, Issue 4; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CONTAINERS
HAZARDS
LIVER
MICROSPHERES
NEOPLASMS
RADIOEMBOLIZATION
RESINS
SAFETY
TOXICITY
VASCULAR DISEASES
YTTRIUM 90