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Title: DNA detection by THz pumping

DNA semiconductor detection and sequencing is considered to be the most promising approach for future discoveries in genome and proteome research which is dramatically dependent on the challenges faced by semiconductor nanotechnologies. DNA pH-sensing with ion-sensitive field effect transistor (ISFET) is well-known to be a successfully applied electronic platform for genetic research. However this method lacks fundamentally in chemical specificity. Here we develop the first ever silicon nanosandwich pump device, which provides both the excitation of DNA fragments’ self-resonant modes and the feedback for current-voltage measurements at room temperature. This device allows direct detection of singlestranded label-free oligonucleotides by measuring their THz frequency response in aqueous solution. These results provide a new insight into the nanobioelectronics for the future real-time technologies of direct gene observations.
Authors:
 [1] ; ;  [2] ; ;  [1]
  1. Russian Academy of Sciences, St. Petersburg Academic University—Nanotechnology Research and Education Centre (Russian Federation)
  2. Russian Academy of Sciences, Ioffe Physicotechnical Institute (Russian Federation)
Publication Date:
OSTI Identifier:
22469831
Resource Type:
Journal Article
Resource Relation:
Journal Name: Semiconductors; Journal Volume: 49; Journal Issue: 7; Other Information: Copyright (c) 2015 Pleiades Publishing, Ltd.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; AQUEOUS SOLUTIONS; ELECTRIC POTENTIAL; EV RANGE; EXCITATION; FEEDBACK; FIELD EFFECT TRANSISTORS; GENES; NANOTECHNOLOGY; OLIGONUCLEOTIDES; PH VALUE; SEMICONDUCTOR MATERIALS; SILICON; SPECIFICITY; TEMPERATURE RANGE 0273-0400 K