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Title: Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome

Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: One was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.
Authors:
;  [1] ;  [2] ;  [3] ;  [1] ;  [4] ; ;  [5] ;  [1]
  1. Brigham and Women’s Hospital, Department of Radiology (United States)
  2. University of Manitoba, Department of Radiology (Canada)
  3. Brigham and Women’s Hospital, Department of Anesthesiology (United States)
  4. Dana Farber Cancer Institute, Department of Medicine (United States)
  5. Brigham and Women’s Hospital, Department of Endocrinology (United States)
Publication Date:
OSTI Identifier:
22469771
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 38; Journal Issue: 5; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; ACTH; ADRENAL GLANDS; ADRENALECTOMY; COMPUTERIZED TOMOGRAPHY; CURRENTS; HYDROCORTISONE; MICROWAVE RADIATION; PATIENTS; REFRACTORIES; THERAPY; WHO