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Title: Single-Centre Experience with Percutaneous Cryoablation of Breast Cancer in 23 Consecutive Non-surgical Patients

AimTo present our single-centre prospective experience on the use of cryoablation (CA) applied to treat primary breast cancer (BC) in a cohort of patients unsuitable for surgical treatment.Materials and MethodsTwenty-three consecutive post-menopausal female patients (median age 85 years; range 56–96) underwent percutaneous CA of unifocal, biopsy-proven BC, under ultrasound/computed tomography (US/CT) guidance. Clinical and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) follow-ups were systematically scheduled at 3, 12, 18 and 24 months. Local tumour control was assessed by comparing baseline and follow-up DCE-MRI.ResultsTwenty-three BC (median size 14 mm) were treated under local anaesthesia (78.3 %) or local anaesthesia and conscious sedation (21.7 %). Median number of cryo-probes applied per session was 2.0. A “dual-freezing” protocol was applied for the first ten patients and a more aggressive “triple-freezing” protocol for the remaining 13. Median follow-up was 14.6 months. Five patients recurred during follow-up and two were successfully re-treated with CA. Five patients presented immediate CA-related complications: four hematomas evolved uneventfully at 3-month follow-up and one skin burn resulted in skin inflammation and skin retraction at 3 and 12 months, respectively.ConclusionsPercutaneous CA is safe and well tolerated for non-resected elderly BC patients. Procedures can be proposed under local anaesthesia only. Given the insulation properties of the breast gland, aggressive CAmore » protocols are required. Prospective studies are needed to better understand the potential role of CA in the local treatment of early BC.« less
Authors:
 [1] ;  [2] ; ; ;  [1] ;  [2] ;  [3] ;  [1]
  1. Institut Bergonié, Comprehensive Cancer Centre, Department of Medical Imaging (France)
  2. Institut Bergonié, Comprehensive Cancer Centre, Department of Surgery (France)
  3. Institut Bergonié, Comprehensive Cancer Centre, Department of Medical Oncology (France)
Publication Date:
OSTI Identifier:
22469746
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 38; Journal Issue: 5; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANESTHESIA; BIOMEDICAL RADIOGRAPHY; BIOPSY; BURNS; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; CONTROL; FEMALES; FREEZING; HEMATOMAS; INFLAMMATION; MAMMARY GLANDS; MATERIALS; NEOPLASMS; NMR IMAGING; PATIENTS; POTENTIALS; PROBES; SCHEDULES; SKIN; UNINTERRUPTIBLE POWER SUPPLIES