Percutaneous Microwave Ablation of Renal Angiomyolipomas

Cristescu, Mircea; Wells, Shane

doi:10.1007/S00270-015-1201-5

Title: Percutaneous Microwave Ablation of Renal Angiomyolipomas

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Abstract

PurposeTo evaluate the safety and efficacy of US-guided percutaneous microwave (MW) ablation in the treatment of renal angiomyolipoma (AML).Materials and MethodsFrom January 2011 to April 2014, seven patients (5 females and 2 males; mean age 51.4) with 11 renal AMLs (9 sporadic type and 2 tuberous sclerosis associated) with a mean size of 3.4 ± 0.7 cm (range 2.4–4.9 cm) were treated with high-powered, gas-cooled percutaneous MW ablation under US guidance. Tumoral diameter, volume, and CT/MR enhancement were measured on pre-treatment, immediate post-ablation, and delayed post-ablation imaging. Clinical symptoms and creatinine were assessed on follow-up visits.ResultsAll ablations were technically successful and no major complications were encountered. Mean ablation parameters were ablation power of 65 W (range 60–70 W), using 456 mL of hydrodissection fluid per patient, over 4.7 min (range 3–8 min). Immediate post-ablation imaging demonstrated mean tumor diameter and volume decreases of 1.8 % (3.4–3.3 cm) and 1.7 % (27.5–26.3 cm{sup 3}), respectively. Delayed imaging follow-up obtained at a mean interval of 23.1 months (median 17.6; range 9–47) demonstrated mean tumor diameter and volume decreases of 29 % (3.4–2.4 cm) and 47 % (27.5–12.1 cm{sup 3}), respectively. Tumoral enhancement decreased on immediate post-procedure and delayed imaging by CT/MR parameters, indicating decreased tumor vascularity. No patients required additional intervention and no patients experienced spontaneous bleeding post-ablation.ConclusionOur early experiencemore »« less

Authors:

Cristescu, Mircea ^[1]; Wells, Shane

University of Wisconsin, Department of Radiology (United States)

Publication Date:: Tue Mar 15 00:00:00 EDT 2016

OSTI Identifier:: 22469573

Resource Type:: Journal Article

Journal Name:: Cardiovascular and Interventional Radiology

Additional Journal Information:: Journal Volume: 39; Journal Issue: 3; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; ADMINISTRATIVE PROCEDURES; BIOMEDICAL RADIOGRAPHY; COMPUTERIZED TOMOGRAPHY; CREATININE; KIDNEYS; MICROWAVE RADIATION; NEOPLASMS; PATIENTS; SAFETY; SYMPTOMS

Citation Formats


                    Cristescu, Mircea, Abel, E. Jason, E-mail: abel@urology.wisc.edu, Wells, Shane, Ziemlewicz, Timothy J., E-mail: tziemlewicz@uwhealth.org, Hedican, Sean P., E-mail: hedican@surgery.wisc.edu, Lubner, Megan G., E-mail: mlubner@uwhealth.org, Hinshaw, J. Louis, E-mail: jhinshaw@uwhealth.org, Brace, Christopher L., E-mail: cbrace@uwhealth.org, and Lee, Fred T., E-mail: flee@uwhealth.org. Percutaneous Microwave Ablation of Renal Angiomyolipomas.  United States: N. p., 2016. 
        Web.  doi:10.1007/S00270-015-1201-5.

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                    Cristescu, Mircea, Abel, E. Jason, E-mail: abel@urology.wisc.edu, Wells, Shane, Ziemlewicz, Timothy J., E-mail: tziemlewicz@uwhealth.org, Hedican, Sean P., E-mail: hedican@surgery.wisc.edu, Lubner, Megan G., E-mail: mlubner@uwhealth.org, Hinshaw, J. Louis, E-mail: jhinshaw@uwhealth.org, Brace, Christopher L., E-mail: cbrace@uwhealth.org, & Lee, Fred T., E-mail: flee@uwhealth.org. Percutaneous Microwave Ablation of Renal Angiomyolipomas.  United States.  https://doi.org/10.1007/S00270-015-1201-5

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                    Cristescu, Mircea, Abel, E. Jason, E-mail: abel@urology.wisc.edu, Wells, Shane, Ziemlewicz, Timothy J., E-mail: tziemlewicz@uwhealth.org, Hedican, Sean P., E-mail: hedican@surgery.wisc.edu, Lubner, Megan G., E-mail: mlubner@uwhealth.org, Hinshaw, J. Louis, E-mail: jhinshaw@uwhealth.org, Brace, Christopher L., E-mail: cbrace@uwhealth.org, and Lee, Fred T., E-mail: flee@uwhealth.org. 2016.  
        "Percutaneous Microwave Ablation of Renal Angiomyolipomas".  United States.  https://doi.org/10.1007/S00270-015-1201-5.

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@article{osti_22469573,

  title        = {Percutaneous Microwave Ablation of Renal Angiomyolipomas},

  author       = {Cristescu, Mircea and Abel, E. Jason, E-mail: abel@urology.wisc.edu and Wells, Shane and Ziemlewicz, Timothy J., E-mail: tziemlewicz@uwhealth.org and Hedican, Sean P., E-mail: hedican@surgery.wisc.edu and Lubner, Megan G., E-mail: mlubner@uwhealth.org and Hinshaw, J. Louis, E-mail: jhinshaw@uwhealth.org and Brace, Christopher L., E-mail: cbrace@uwhealth.org and Lee, Fred T., E-mail: flee@uwhealth.org},

  abstractNote = {PurposeTo evaluate the safety and efficacy of US-guided percutaneous microwave (MW) ablation in the treatment of renal angiomyolipoma (AML).Materials and MethodsFrom January 2011 to April 2014, seven patients (5 females and 2 males; mean age 51.4) with 11 renal AMLs (9 sporadic type and 2 tuberous sclerosis associated) with a mean size of 3.4 ± 0.7 cm (range 2.4–4.9 cm) were treated with high-powered, gas-cooled percutaneous MW ablation under US guidance. Tumoral diameter, volume, and CT/MR enhancement were measured on pre-treatment, immediate post-ablation, and delayed post-ablation imaging. Clinical symptoms and creatinine were assessed on follow-up visits.ResultsAll ablations were technically successful and no major complications were encountered. Mean ablation parameters were ablation power of 65 W (range 60–70 W), using 456 mL of hydrodissection fluid per patient, over 4.7 min (range 3–8 min). Immediate post-ablation imaging demonstrated mean tumor diameter and volume decreases of 1.8 % (3.4–3.3 cm) and 1.7 % (27.5–26.3 cm{sup 3}), respectively. Delayed imaging follow-up obtained at a mean interval of 23.1 months (median 17.6; range 9–47) demonstrated mean tumor diameter and volume decreases of 29 % (3.4–2.4 cm) and 47 % (27.5–12.1 cm{sup 3}), respectively. Tumoral enhancement decreased on immediate post-procedure and delayed imaging by CT/MR parameters, indicating decreased tumor vascularity. No patients required additional intervention and no patients experienced spontaneous bleeding post-ablation.ConclusionOur early experience with high-powered, gas-cooled percutaneous MW ablation demonstrates it to be a safe and effective modality to devascularize and decrease the size of renal AMLs.},

  doi          = {10.1007/S00270-015-1201-5},

  url          = {https://www.osti.gov/biblio/22469573},
  journal      = {Cardiovascular and Interventional Radiology},

  issn         = {0174-1551},

  number       = 3,

  volume       = 39,

  place        = {United States},

  year         = {Tue Mar 15 00:00:00 EDT 2016},

  month        = {Tue Mar 15 00:00:00 EDT 2016}

}

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