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Title: Dosimetric effect on pediatric conformal treatment plans using dynamic jaw with Tomotherapy HDA

It is important to minimize the radiation dose delivered to healthy tissues in pediatric cancer treatment because of the risk of secondary malignancies. Tomotherapy HDA provides a dynamic jaw (DJ) delivery mode that creates a sharper penumbra at the craniocaudal ends of a target in addition to a fixed jaw (FJ) delivery mode. The purpose of this study was to evaluate its dosimetric effect on the pediatric cancer cases. We included 6 pediatric cases in this study. The dose profiles and plan statistics—target dose conformity, uniformity, organ-at-risk (OAR) mean dose, beam-on time, and integral dose—were compared for each case. Consequently, the target dose coverage and uniformity were similar for different jaw settings. The OAR dose sparing depended on its relative location to the target and disease sites. For example, in the head and neck cancer cases, the brain stem dose using DJ 2.5 was reduced by more than two-fold (2.4 Gy vs. 6.3 Gy) than that obtained with FJ 2.5. The integral dose with DJ 2.5 decreased by more than 9% compared with that with FJ 2.5. Thus, using dynamic jaw in pediatric cases could be critical to reduce a probability of a secondary malignancy.
Authors:
 [1] ;  [2] ; ; ; ; ; ;  [1]
  1. Department of Radiation Oncology, University of Arkansas Medical Sciences, Little Rock, AR (United States)
  2. Department of Radiation Oncology, Kyung Hee University Hospital, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
22462447
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 40; Journal Issue: 3; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL TISSUES; BRAIN; COLLIMATORS; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; CT-GUIDED RADIOTHERAPY; HEAD; INTEGRAL DOSES; NECK; NEOPLASMS; PEDIATRICS; PROBABILITY; STATISTICS