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Title: Fractionated changes in prostate cancer radiotherapy using cone-beam computed tomography

The high mobility of the bladder and the rectum causes uncertainty in radiation doses prescribed to patients with prostate cancer who undergo radiotherapy (RT) multifraction treatments. The purpose of this study was to estimate the dose received by the bladder, rectum, and prostate from multifraction treatments using daily cone-beam computed tomography (CBCT). Overall, 28 patients with prostate cancer who planned to receive radiation treatments were enrolled in the study. The acquired CBCT before the treatment delivery was registered with the planning CT to map the dose distribution used in the treatment plan for estimating the received dose during clinical treatment. For all 28 patients with 112 data sets, the mean percentage differences (± standard deviation) in the volume and radiation dose were 44% (± 41) and 18% (± 17) for the bladder, 20% (± 21) and 2% (± 2) for the prostate, and 36% (± 29) and 22% (± 15) for the rectum, respectively. Substantial differences between the volumes and radiation dose and those specified in treatment plans were observed. Besides the use of image-guided RT to improve patient setup accuracy, further consideration of large changes in bladder and rectum volumes is strongly suggested when using external beam radiation formore » prostate cancer.« less
Authors:
 [1] ;  [2] ;  [1] ;  [1] ;  [2] ;  [1] ;  [3] ;  [4]
  1. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City, Taiwan (China)
  2. (China)
  3. Department of Radiation Oncology, China Medical University Hospital, Taichung City, Taiwan (China)
  4. Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States)
Publication Date:
OSTI Identifier:
22462443
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 40; Journal Issue: 3; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ACCURACY; BLADDER; COMPUTERIZED TOMOGRAPHY; NEOPLASMS; PATIENTS; PLANNING; PROSTATE; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOTHERAPY; RECTUM