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Title: An efficient Volumetric Arc Therapy treatment planning approach for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT)

Abstract

An efficient and simple class solution is proposed for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT) planning using the Volumetric Arc Therapy (VMAT) delivery technique following the NRG Oncology protocol NRG-CC001 treatment planning guidelines. The whole-brain planning target volume (PTV) was subdivided into subplanning volumes that lie in plane and out of plane with the hippocampal-avoidance volume. To further improve VMAT treatment plans, a partial-field dual-arc technique was developed. Both the arcs were allowed to overlap on the in-plane subtarget volume, and in addition, one arc covered the superior out-of-plane sub-PTV, while the other covered the inferior out-of-plane subtarget volume. For all plans (n = 20), the NRG-CC001 protocol dose-volume criteria were met. Mean values of volumes for the hippocampus and the hippocampal-avoidance volume were 4.1 cm{sup 3} ± 1.0 cm{sup 3} and 28.52 cm{sup 3} ± 3.22 cm{sup 3}, respectively. For the PTV, the average values of D{sub 2%} and D{sub 98%} were 36.1 Gy ± 0.8 Gy and 26.2 Gy ± 0.6 Gy, respectively. The hippocampus D{sub 100%} mean value was 8.5 Gy ± 0.2 Gy and the maximum dose was 15.7 Gy ± 0.3 Gy. The corresponding plan quality indices were 0.30 ± 0.01 (homogeneity index), 0.94 ± 0.01more » (target conformality), and 0.75 ± 0.02 (confirmation number). The median total monitor unit (MU) per fraction was 806 MU (interquartile range [IQR]: 792 to 818 MU) and the average beam total delivery time was 121.2 seconds (IQR: 120.6 to 121.35 seconds). All plans passed the gamma evaluation using the 5-mm, 4% criteria, with γ > 1 of not more than 9.1% data points for all fields. An efficient and simple planning class solution for HA-WBRT using VMAT has been developed that allows all protocol constraints of NRG-CC001 to be met.« less

Authors:
 [1];  [2]; ; ; ; ; ; ;  [1]
  1. Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY (United States)
  2. Department of Medical Physics, University of Wisconsin, Madison, WI (United States)
Publication Date:
OSTI Identifier:
22462440
Resource Type:
Journal Article
Journal Name:
Medical Dosimetry
Additional Journal Information:
Journal Volume: 40; Journal Issue: 3; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; AVOIDANCE; HIPPOCAMPUS; LIMITING VALUES; MONITORS; PLANNING; RADIATION DOSES; RADIOTHERAPY; RECOMMENDATIONS

Citation Formats

Shen, Jin, Bender, Edward, Yaparpalvi, Ravindra, Kuo, Hsiang-Chi, Basavatia, Amar, Hong, Linda, Bodner, William, Garg, Madhur K., Kalnicki, Shalom, Tomé, Wolfgang A., E-mail: wtome@montefiore.org, and Department of Medical Physics, University of Wisconsin, Madison, WI. An efficient Volumetric Arc Therapy treatment planning approach for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT). United States: N. p., 2015. Web. doi:10.1016/J.MEDDOS.2014.11.007.
Shen, Jin, Bender, Edward, Yaparpalvi, Ravindra, Kuo, Hsiang-Chi, Basavatia, Amar, Hong, Linda, Bodner, William, Garg, Madhur K., Kalnicki, Shalom, Tomé, Wolfgang A., E-mail: wtome@montefiore.org, & Department of Medical Physics, University of Wisconsin, Madison, WI. An efficient Volumetric Arc Therapy treatment planning approach for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT). United States. https://doi.org/10.1016/J.MEDDOS.2014.11.007
Shen, Jin, Bender, Edward, Yaparpalvi, Ravindra, Kuo, Hsiang-Chi, Basavatia, Amar, Hong, Linda, Bodner, William, Garg, Madhur K., Kalnicki, Shalom, Tomé, Wolfgang A., E-mail: wtome@montefiore.org, and Department of Medical Physics, University of Wisconsin, Madison, WI. 2015. "An efficient Volumetric Arc Therapy treatment planning approach for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT)". United States. https://doi.org/10.1016/J.MEDDOS.2014.11.007.
@article{osti_22462440,
title = {An efficient Volumetric Arc Therapy treatment planning approach for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT)},
author = {Shen, Jin and Bender, Edward and Yaparpalvi, Ravindra and Kuo, Hsiang-Chi and Basavatia, Amar and Hong, Linda and Bodner, William and Garg, Madhur K. and Kalnicki, Shalom and Tomé, Wolfgang A., E-mail: wtome@montefiore.org and Department of Medical Physics, University of Wisconsin, Madison, WI},
abstractNote = {An efficient and simple class solution is proposed for hippocampal-avoidance whole-brain radiation therapy (HA-WBRT) planning using the Volumetric Arc Therapy (VMAT) delivery technique following the NRG Oncology protocol NRG-CC001 treatment planning guidelines. The whole-brain planning target volume (PTV) was subdivided into subplanning volumes that lie in plane and out of plane with the hippocampal-avoidance volume. To further improve VMAT treatment plans, a partial-field dual-arc technique was developed. Both the arcs were allowed to overlap on the in-plane subtarget volume, and in addition, one arc covered the superior out-of-plane sub-PTV, while the other covered the inferior out-of-plane subtarget volume. For all plans (n = 20), the NRG-CC001 protocol dose-volume criteria were met. Mean values of volumes for the hippocampus and the hippocampal-avoidance volume were 4.1 cm{sup 3} ± 1.0 cm{sup 3} and 28.52 cm{sup 3} ± 3.22 cm{sup 3}, respectively. For the PTV, the average values of D{sub 2%} and D{sub 98%} were 36.1 Gy ± 0.8 Gy and 26.2 Gy ± 0.6 Gy, respectively. The hippocampus D{sub 100%} mean value was 8.5 Gy ± 0.2 Gy and the maximum dose was 15.7 Gy ± 0.3 Gy. The corresponding plan quality indices were 0.30 ± 0.01 (homogeneity index), 0.94 ± 0.01 (target conformality), and 0.75 ± 0.02 (confirmation number). The median total monitor unit (MU) per fraction was 806 MU (interquartile range [IQR]: 792 to 818 MU) and the average beam total delivery time was 121.2 seconds (IQR: 120.6 to 121.35 seconds). All plans passed the gamma evaluation using the 5-mm, 4% criteria, with γ > 1 of not more than 9.1% data points for all fields. An efficient and simple planning class solution for HA-WBRT using VMAT has been developed that allows all protocol constraints of NRG-CC001 to be met.},
doi = {10.1016/J.MEDDOS.2014.11.007},
url = {https://www.osti.gov/biblio/22462440}, journal = {Medical Dosimetry},
issn = {0958-3947},
number = 3,
volume = 40,
place = {United States},
year = {Thu Oct 01 00:00:00 EDT 2015},
month = {Thu Oct 01 00:00:00 EDT 2015}
}