skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Phosphatidylinositol 4-kinases: Function, structure, and inhibition

Abstract

The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and two type III enzymes (α and β). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.

Authors:
;
Publication Date:
OSTI Identifier:
22462332
Resource Type:
Journal Article
Journal Name:
Experimental Cell Research
Additional Journal Information:
Journal Volume: 337; Journal Issue: 2; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0014-4827
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CRYSTAL STRUCTURE; DRUGS; HUMAN POPULATIONS; INHIBITION; MEDICINE; MEMBRANES; PHOSPHATES; PHOSPHOTRANSFERASES; POTENTIALS; VIRUSES

Citation Formats

Boura, Evzen, and Nencka, Radim. Phosphatidylinositol 4-kinases: Function, structure, and inhibition. United States: N. p., 2015. Web. doi:10.1016/J.YEXCR.2015.03.028.
Boura, Evzen, & Nencka, Radim. Phosphatidylinositol 4-kinases: Function, structure, and inhibition. United States. https://doi.org/10.1016/J.YEXCR.2015.03.028
Boura, Evzen, and Nencka, Radim. 2015. "Phosphatidylinositol 4-kinases: Function, structure, and inhibition". United States. https://doi.org/10.1016/J.YEXCR.2015.03.028.
@article{osti_22462332,
title = {Phosphatidylinositol 4-kinases: Function, structure, and inhibition},
author = {Boura, Evzen and Nencka, Radim},
abstractNote = {The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking to and from the Golgi. Humans have two type II PI4Ks (α and β) and two type III enzymes (α and β). Recently, the crystal structures were solved for both type II and type III kinase revealing atomic details of their function. Importantly, the type III PI4Ks are hijacked by +RNA viruses to create so-called membranous web, an extensively phosphorylated and modified membrane system dedicated to their replication. Therefore, selective and potent inhibitors of PI4Ks have been developed as potential antiviral agents. Here we focus on the structure and function of PI4Ks and their potential in human medicine.},
doi = {10.1016/J.YEXCR.2015.03.028},
url = {https://www.osti.gov/biblio/22462332}, journal = {Experimental Cell Research},
issn = {0014-4827},
number = 2,
volume = 337,
place = {United States},
year = {Thu Oct 01 00:00:00 EDT 2015},
month = {Thu Oct 01 00:00:00 EDT 2015}
}