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Title: Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-κB and STAT3 signaling pathway in human keratinocytes. In addition, keratinocyte proliferation was markedly inhibited by cucurbitacin B. The potential beneficial effect of cucurbitacin B on psoriasis was further validated in imiquimod-induced psoriasiform dermatitis of experimental animal. Topical application of cucurbitacin B resulted in significant reduction of epidermal hyperplasia and inflammatory cytokines production, and ameliorated the psoriatic symptom. Taken together, these results suggest that cucurbitacin B may be a potential candidate for the treatment of psoriasis. - Highlights: • Cucurbitacin B has a potential for inhibiting the growth of keratinocytes. • Cucurbitacin B inhibits imiquimod-induced inflammatory reaction in keratinocytes. • Cucurbitacin B inhibits imiquimod-induced psoriasiform dermatitis in experimental animal.
Authors:
; ; ;  [1] ;  [2] ;  [3] ; ; ; ; ;  [1] ;  [1] ;  [4]
  1. Department of Dermatology, School of Medicine, Chungnam National University, Daejeon (Korea, Republic of)
  2. Department of Dermatology, School of Medicine, Gyeongsang National University, Jinju (Korea, Republic of)
  3. Department of Anatomy, School of Medicine, Chungnam National University, Daejeon (Korea, Republic of)
  4. (Korea, Republic of)
Publication Date:
OSTI Identifier:
22462005
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 459; Journal Issue: 4; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; DERMATITIS; HUMAN POPULATIONS; INFLAMMATION; LYMPHOKINES; PATHOGENESIS; PLANT GROWTH; PSORIASIS; SIGNALS; SKIN