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Title: Bioaccumulation of hydroxylated polychlorinated biphenyls and pentachlorophenol in the serum of northern elephant seal pups (Mirounga angustirostris)

Northern elephant seals (NES) (Mirounga angustirostris) from the Año Nuevo State Reserve (CA, USA) were sampled at 1-, 4-, 7- and 10-week post-weaning. Concentrations of hydroxylated polychlorinated biphenyls (HO-PCBs) and their parent PCBs were measured in the serum of each individual. The ΣHO-PCB concentrations in the serum increased significantly between early and late fast (from 282±20 to 529±31 pg/mL). This increase might result from a mobilisation of HO-PCBs transferred from the mother during gestation and/or lactation and stored in the pup's liver. Food deprivation has been shown to exacerbate biotransformation capacities in mammals, birds and fish. The HO-penta-CBs was the predominant homologue group, followed by HO-hexa-CBs and HO-hepta-CBs. No preferential pathway for the metabolism of HO-PCBs (HO-direct insertion or NIH-shift of a chlorine atom) could be evidenced. The concentrations of pentachlorophenol (PCP) in the serum of weaned NES increased from 103±7 pg/mL at early fast to 246±41 pg/mL at late fast, which is within the range of PCP concentrations usually encountered in marine mammals. - Highlights: • Σ HO-PCB concentrations in serum significantly increased between early and late fast. • The HO-penta-CBs were the predominant homologue group measured in serum. • No preferential pathway for the metabolism of HO-PCBs couldmore » be evidenced. • PCP concentrations in serum significantly increased between early and late fast.« less
Authors:
 [1] ;  [2] ;  [1] ;  [3] ;  [2] ;  [2] ;  [4] ;  [1]
  1. Institut des Sciences de la Vie, UCLouvain, Croix du Sud 2/L7.05.08, 1348 Louvain-la-Neuve (Belgium)
  2. Department of Pharmaceutical Sciences, Toxicological Center, Campus Drie Eiken, Universiteit Antwerpen, Universiteitsplein 1, 2610 Wilrijk (Belgium)
  3. Department of Biology, Sonoma State University, 1801 East Cotati Ave, Rohnert Park, CA 94928 (United States)
  4. (Romania)
Publication Date:
OSTI Identifier:
22447571
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 136; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; ABUNDANCE; ATOMS; BIOLOGICAL ACCUMULATION; BIRDS; CAPACITY; CHLORINE; CONCENTRATION RATIO; ECOLOGICAL CONCENTRATION; FOOD; LACTATION; LIVER; MAMMALS; METABOLISM; MOTHS; POLYCHLORINATED BIPHENYLS; SEALS; USA