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Title: Effects of blood lead levels on airflow limitations in Korean adults: Findings from the 5th KNHNES 2011

This study aimed to examine whether blood levels of heavy metals, such as lead, mercury and cadmium, are related with pulmonary function in Korean adults. This investigation included 870 Korean adults (≥40 years) who received pulmonary function testing in the Korea National Health and Nutrition Examination Survey (KNHANES) V-2, 2011. Data of blood levels of heavy metals, pulmonary function tests and anthropometric measurements were acquired. Blood lead levels showed inverse correlations with the FEV{sub 1}/FVC ratio before (r=−0.276, p<0.001) and after adjustment of multiple compounding factors (r=−0.115, p=0.001). A logistic multiple regression analysis revealed that blood lead levels were a significant influencing factor for the FEV{sub 1}/FVC ratio (β=−0.017, p=0.001, adjusted R{sup 2}=0.267). The odds ratios (ORs) for the FEV{sub 1}/FVC ratio were significantly lower in the highest tertile group of the blood lead levels than in the lowest tertile group in Model 1 (OR=0.007, 95% CI=0.000−0.329) and Model 2 (OR=0.006, 95% CI=0.000−0.286). These findings imply that environmental exposure to lead might be an important factor that may cause airflow limitations in Korean adults. - Highlights: • Blood lead levels showed inverse correlations with the FEV{sub 1}/FVC ratio. • Blood lead level was a significant influencing factor for the FEV{submore » 1}/FVC ratio. • ORs for FEV{sub 1}/FVC were lower in the highest blood lead group than in the lowest group. • Environmental exposure to lead might be an important factor for airflow limitations.« less
Authors:
 [1] ;  [2] ;  [1] ;  [3]
  1. Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul 120-749 (Korea, Republic of)
  2. Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-749 (Korea, Republic of)
  3. (Korea, Republic of)
Publication Date:
OSTI Identifier:
22447563
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 136; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; BLOOD; CADMIUM; DISEASES; ENVIRONMENTAL EXPOSURE; HEAVY METALS; LEAD; MERCURY; NORTH KOREA; NUTRITION; REGRESSION ANALYSIS; TESTING; WHO