skip to main content

Title: Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population

Background: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population. Materials and methods: Using 2005–2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender. Results: Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women. Conclusion: PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs. - Highlights: • Most serum PFCs are not associated with clinically evident Gilbert syndrome. • However, serum perfluorohexanoic acid is positively associated. • The investigation addresses the clinical presentation, not the genetic mutation.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [4] ;  [5]
  1. Cancer Center, School of Public Health, West Virginia University, Morgantown, WV 265050-9190 (United States)
  2. (China)
  3. Department of Occupational and Environmental Health, School of Public Health, West Virginia University (United States)
  4. (United States)
  5. Department of Biostatistics, School Public Health, West Virginia University (United States)
Publication Date:
OSTI Identifier:
22447552
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 135; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 54 ENVIRONMENTAL SCIENCES; ABUNDANCE; BILIRUBIN; CARBON 8; DRUGS; ECOLOGICAL CONCENTRATION; ENZYMES; EXCRETION; GENE MUTATIONS; HAZARDS; MATERIALS; METABOLISM; PHENOTYPE; PUBLIC OPINION; SMOKES; STANDARDS; XENOBIOTICS