Blood cadmium levels are associated with a decline in lung function in males

Oh, Chang-Mo; Oh, In-Hwan; Lee, Jong-Keun; Park, Yoon Hyung; Choe, Bong-Keun; Yoon, Tai-Young; Choi, Joong-Myung

doi:10.1016/J.ENVRES.2014.04.008

Title: Blood cadmium levels are associated with a decline in lung function in males

Full Record
Other Related Research

Abstract

Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43).more »« less

Authors:

Oh, Chang-Mo ^[1]; Oh, In-Hwan; Lee, Jong-Keun ^[1]; Park, Yoon Hyung ^[2]; Choe, Bong-Keun; Yoon, Tai-Young ^[1]; Choi, Joong-Myung ^[1]

Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of)
Departments of Preventive Medicine, School of Medicine, Soonchunhyang University, Seoul (Korea, Republic of)

Publication Date:: Tue Jul 15 00:00:00 EDT 2014

OSTI Identifier:: 22447523

Resource Type:: Journal Article

Journal Name:: Environmental Research

Additional Journal Information:: Journal Volume: 132; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; AUGMENTATION; BLOOD; CADMIUM; DISEASES; FEMALES; LUNGS; MALES; MARINE SURVEYS; NORTH KOREA; NUTRITION; SMOKES; WHO

Citation Formats


                    Oh, Chang-Mo, The Korea Central Cancer Registry, National Cancer Center, Goyang, Oh, In-Hwan, Lee, Jong-Keun, Park, Yoon Hyung, Choe, Bong-Keun, Yoon, Tai-Young, and Choi, Joong-Myung. Blood cadmium levels are associated with a decline in lung function in males.  United States: N. p., 2014. 
        Web.  doi:10.1016/J.ENVRES.2014.04.008.

Copy to clipboard


                    Oh, Chang-Mo, The Korea Central Cancer Registry, National Cancer Center, Goyang, Oh, In-Hwan, Lee, Jong-Keun, Park, Yoon Hyung, Choe, Bong-Keun, Yoon, Tai-Young, & Choi, Joong-Myung. Blood cadmium levels are associated with a decline in lung function in males.  United States.  https://doi.org/10.1016/J.ENVRES.2014.04.008

Copy to clipboard


                    Oh, Chang-Mo, The Korea Central Cancer Registry, National Cancer Center, Goyang, Oh, In-Hwan, Lee, Jong-Keun, Park, Yoon Hyung, Choe, Bong-Keun, Yoon, Tai-Young, and Choi, Joong-Myung. 2014.  
        "Blood cadmium levels are associated with a decline in lung function in males".  United States.  https://doi.org/10.1016/J.ENVRES.2014.04.008.

Copy to clipboard


                    
@article{osti_22447523,

  title        = {Blood cadmium levels are associated with a decline in lung function in males},

  author       = {Oh, Chang-Mo and The Korea Central Cancer Registry, National Cancer Center, Goyang and Oh, In-Hwan and Lee, Jong-Keun and Park, Yoon Hyung and Choe, Bong-Keun and Yoon, Tai-Young and Choi, Joong-Myung},

  abstractNote = {Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43). Conclusions: A higher blood cadmium level, within the normal range, was associated with COPD in males, including those who had never smoked. However, there was no significant association between blood cadmium levels and COPD in females. - Highlights: • Elevated blood cadmium level is associated with chronic obstructive pulmonary disease in male. • This association can be seen even in never smoked male. • However, this association is present only in male, but not in female.},

  doi          = {10.1016/J.ENVRES.2014.04.008},

  url          = {https://www.osti.gov/biblio/22447523},
  journal      = {Environmental Research},

  issn         = {0013-9351},

  number       = ,

  volume       = 132,

  place        = {United States},

  year         = {Tue Jul 15 00:00:00 EDT 2014},

  month        = {Tue Jul 15 00:00:00 EDT 2014}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1016/J.ENVRES.2014.04.008

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

COPD risk among older construction workers—Updated analyses 2020

Journal Article Dement, John; Cloeren, Marianne; Ringen, Knut; ... - American Journal of Industrial Medicine

Abstract Background A 2010 study of construction workers participating in medical screening programs at the Department of Energy (DOE) nuclear facilities demonstrated increased chronic obstructive pulmonary disease (COPD) risk. The current study of a larger worker cohort allowed for a more nuanced analysis of COPD risk, including for employment beginning after the mid‐1990s. Methods Study participants included 17,941 workers with demographic and smoking data and spirometry with a minimum of three recorded expiratory efforts and reproducibility of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV ₁ ) of 0.2 L or less. COPD was defined as a FEVmore »« less
https://doi.org/10.1002/ajim.23244
Occupational exposures and chronic respiratory symptoms: a population-based study

Technical Report Korn, R; Dockery, D; Speizer, F; ...

Data from a random sample of 8515 white adults residing in six cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms. 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or to fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalence of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposedmore »« less
Long-term exposure of adults to outdoor air pollution is associated with increased airway obstruction and higher prevalence of bronchial hyperresponsiveness

Journal Article Jammres, Y; Delpierre, S; Burnet, H; ... - Archives of Environmental Health

The authors studied the association between long-term exposure to outdoor air pollution and the severity of obstructive pulmonary disease and prevalence of bronchial hyperreactivity to {beta}2 agonists in two groups of adult patients who were of similar ages and who had similar smoking habits. The subjects lived in downtown districts or in the outer suburbs of Marseilles, the neighborhood that contained air samplers. The regions were similar with respect to sulfur dioxide levels, but levels of nitric oxides and particulate matter were higher in the downtown area than the suburbs. The authors assessed airway obstruction, as determined by a decreasemore »« less
https://doi.org/10.1080/00039899809605723
Occupational exposures and chronic respiratory symptoms. A population-based study

Journal Article Korn, R; Dockery, D; Speizer, F; ... - Am. Rev. Respir. Dis.; (United States)

Data from a random sample of 8515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed tomore »« less
https://doi.org/10.1164/ajrccm/136.2.298
The relationship between the bone mineral density and urinary cadmium concentration of residents in an industrial complex

Journal Article Shin, Minah; Paek, Domyung; Yoon, Chungsik - Environmental Research

Background: An association between cadmium exposure and bone mineral density (BMD) has been demonstrated in elderly women, but has not been well studied in youths and men. Some studies report either no or a weak association between cadmium exposure and bone damage. Objectives: This study was designed to investigate the relationship between the urinary cadmium (U-Cd) levels and BMD of females and males of all ages. Methods: A total of 804 residents near an industrial complex were surveyed in 2007. U-Cd and BMD on the heel (non-dominant calcaneus) were analyzed with AAS-GTA and Dual-Energy X-ray absorptiometry, respectively. Demographic characteristics weremore »« less
https://doi.org/10.1016/J.ENVRES.2010.11.010

Similar Records