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Title: Elevated levels of plasma uric acid and its relation to hypertension in arsenic-endemic human individuals in Bangladesh

Blood uric acid has been recognized as a putative marker for cardiovascular diseases (CVDs). CVDs are the major causes of arsenic-related morbidity and mortality. However, the association of arsenic exposure with plasma uric acid (PUA) levels in relation to CVDs has not yet been explored. This study for the first time demonstrated the associations of arsenic exposure with PUA levels and its relationship with hypertension. A total of 483 subjects, 322 from arsenic-endemic and 161 from non-endemic areas in Bangladesh were recruited as study subjects. Arsenic concentrations in the drinking water, hair and nails of the study subjects were measured by inductively coupled plasma mass spectroscopy. PUA levels were measured using a colorimetric method. We found that PUA levels were significantly (p < 0.001) higher in males and females living in arsenic-endemic areas than those in non-endemic area. Arsenic exposure (water, hair and nail arsenic) levels showed significant positive correlations with PUA levels. In multiple regression analyses, arsenic exposure levels were found to be the most significant contributors on PUA levels among the other variables that included age, body mass index, blood urea nitrogen, and smoking. There were dose–response relationships between arsenic exposure and PUA levels. Furthermore, diastolic and systolicmore » blood pressure showed significant positive correlations with PUA levels. Finally, the average PUA levels were significantly higher in the hypertensive group than those in the normotensive group in both males and females living in arsenic-endemic areas. These results suggest that arsenic exposure-related elevation of PUA levels may be implicated in arsenic-induced CVDs. - Highlights: • PUA levels were higher in arsenic-endemic subjects than in non-endemic subjects. • Drinking water, hair and nail arsenic showed significant associations with PUA levels. • Drinking water, hair and nail arsenic showed dose–response relationships with PUA. • Arsenic-endemic hypertensive study subjects had elevated levels of PUA. • Increased PUA levels may be implicated in arsenic-induced CVDs.« less
Authors:
 [1] ;  [2] ; ;  [1] ;  [3] ;  [4] ; ; ; ; ; ; ; ; ; ;  [1] ; ;  [5] ;  [1]
  1. Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205 (Bangladesh)
  2. (Bangladesh)
  3. Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003 (Bangladesh)
  4. Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902 (Bangladesh)
  5. Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514 (Japan)
Publication Date:
OSTI Identifier:
22439904
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 281; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARSENIC; BANGLADESH; BLOOD; BLOOD PRESSURE; CONCENTRATION RATIO; DISEASE INCIDENCE; DOSES; DRINKING WATER; HAIR; HUMAN POPULATIONS; HYPERTENSION; MOLECULES; MORTALITY; NAILS; REGRESSION ANALYSIS; SMOKES; UREA; URIC ACID