Role of the Technical Aspects of Hypofractionated Radiation Therapy Treatment of Prostate Cancer: A Review

Journal Article · Thu Jan 01 00:00:00 EST 2015 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2014.08.006· OSTI ID:22423854

Clemente, Stefania ^[1]; Nigro, Roberta ^[2]; Oliviero, Caterina ^[1]; Marchioni, Chiara ^[2]; Esposito, Marco ^[3]; Giglioli, Francesca Romana ^[4]; Mancosu, Pietro ^[5]; Marino, Carmelo ^[6]; Russo, Serenella ^[3]; Stasi, Michele ^[7]; Strigari, Lidia ^[8]; Veronese, Ivan ^[9]; Landoni, Valeria ^[8]

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1. Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Potenza (Italy)
2. Azienda Sanitaria Locale Rieti, Roma (Italy)
3. Azienda Sanitaria, Firenze (Italy)
4. Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino (Italy)
5. Humanitas Clinical and Research Hospital, Rozzano, Milano (Italy)
6. Humanitas Centro Catanese di Oncologia, Catania (Italy)
7. Azienda Ospedaliera Ordine Mauriziano di Torino, Torino (Italy)
8. Istituto Nazionale Tumori Regina Elena, Roma (Italy)
9. Universita' degli Studi di Milano, Milano (Italy)

The increasing use of moderate (<35 fractions) and extreme (<5 fractions) hypofractionated radiation therapy in prostate cancer is yielding favorable results, both in terms of maintained biochemical response and toxicity. Several hypofractionation (HF) schemes for the treatment of prostate cancer are available, although there is considerable variability in the techniques used to manage intra-/interfraction motion and deliver radiation doses. We performed a review of the published studies on HF regimens as a topic of interest for the Stereotactic Ablative Radiotherapy working group, which is part of the Italian Association of Medical Physics. Aspects of organ motion management (imaging for contouring, target volume definition, and rectum/bladder preparation) and treatment delivery (prostate localization, image guided radiation therapy strategy and frequency) were evaluated and categorized to assess outcome relative to disease control and toxicity. Despite the heterogeneity of the data, some interesting trends that emerged from the review might be useful in identifying an optimum HF strategy.

• OSTI ID: 22423854
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 91, Issue 1; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
BLADDER
FRACTIONATED IRRADIATION
NEOPLASMS
PROSTATE
RADIATION DOSES
RADIOTHERAPY
RECTUM
REVIEWS
TOXICITY