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Title: Multi-institutional Feasibility Study of a Fast Patient Localization Method in Total Marrow Irradiation With Helical Tomotherapy: A Global Health Initiative by the International Consortium of Total Marrow Irradiation

Purpose: To develop, characterize, and implement a fast patient localization method for total marrow irradiation. Methods and Materials: Topographic images were acquired using megavoltage computed tomography (MVCT) detector data by delivering static orthogonal beams while the couch traversed through the gantry. Geometric and detector response corrections were performed to generate a megavoltage topogram (MVtopo). We also generated kilovoltage topograms (kVtopo) from the projection data of 3-dimensional CT images to reproduce the same geometry as helical tomotherapy. The MVtopo imaging dose and the optimal image acquisition parameters were investigated. A multi-institutional phantom study was performed to verify the image registration uncertainty. Forty-five MVtopo images were acquired and analyzed with in-house image registration software. Results: The smallest jaw size (front and backup jaws of 0) provided the best image contrast and longitudinal resolution. Couch velocity did not affect the image quality or geometric accuracy. The MVtopo dose was less than the MVCT dose. The image registration uncertainty from the multi-institutional study was within 2.8 mm. In patient localization, the differences in calculated couch shift between the registration with MVtopo-kVtopo and MVCT-kVCT images in lateral, cranial–caudal, and vertical directions were 2.2 ± 1.7 mm, 2.6 ± 1.4 mm, and 2.7 ± 1.1 mm, respectively. The imaging time in MVtopo acquisition at the couch speedmore » of 3 cm/s was <1 minute, compared with ≥15 minutes in MVCT for all patients. Conclusion: Whole-body MVtopo imaging could be an effective alternative to time-consuming MVCT for total marrow irradiation patient localization.« less
Authors:
 [1] ; ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [3] ;  [8] ;  [3] ;  [5] ;  [9] ;  [10] ;  [11] ;
  1. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota (United States)
  2. Department of Radiation Oncology, Instituto Nazionale per la Ricerca sul Cancro–National Institute for Cancer Research and University of Genoa, Genoa (Italy)
  3. Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States)
  4. Department of Radiation Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice (Poland)
  5. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
  6. Department of Therapeutic Radiology, University of Minnesota, Minneapolis, Minnesota (United States)
  7. (United States)
  8. Department of Radiotherapy, Universitair Ziekenhuis Brussel, Brussels (Belgium)
  9. Department of Radiation Oncology, Integrated Center of Oncology–René Gauducheau, Saint-Herblain Cédex (France)
  10. Divisions of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota (United States)
  11. Department of Medicine, University of Minnesota, Minneapolis, Minnesota (United States)
Publication Date:
OSTI Identifier:
22423836
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 91; Journal Issue: 1; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; BIOMEDICAL RADIOGRAPHY; CAT SCANNING; COMPUTER CODES; CT-GUIDED RADIOTHERAPY; FEASIBILITY STUDIES; GEOMETRY; IRRADIATION; PATIENTS; PHANTOMS; RADIATION DOSES; THREE-DIMENSIONAL CALCULATIONS