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Title: Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms

Abstract

Purpose: To present a method for calculating dose-volume histograms (DVH's) to the active bone marrow (ABM) of patients who had undergone radiation therapy (RT) and subsequently developed leukemia. Methods and Materials: The study focuses on 15 patients treated between 1961 and 1996. Whole-body RT planning computed tomographic (CT) data were not available. We therefore generated representative whole-body CTs similar to patient anatomy. In addition, we developed a method enabling us to obtain information on the density distribution of ABM all over the skeleton. Dose could then be calculated in a series of points distributed all over the skeleton in such a way that their local density reflected age-specific data for ABM distribution. Dose to particular regions and dose-volume histograms of the entire ABM were estimated for all patients. Results: Depending on patient age, the total number of dose calculation points generated ranged from 1,190,970 to 4,108,524. The average dose to ABM ranged from 0.3 to 16.4 Gy. Dose-volume histograms analysis showed that the median doses (D{sub 50%}) ranged from 0.06 to 12.8 Gy. We also evaluated the inhomogeneity of individual patient ABM dose distribution according to clinical situation. It was evident that the coefficient of variation of the dose for the wholemore » ABM ranged from 1.0 to 5.7, which means that the standard deviation could be more than 5 times higher than the mean. Conclusions: For patients with available long-term follow-up data, our method provides reconstruction of dose-volume data comparable to detailed dose calculations, which have become standard in modern CT-based 3-dimensional RT planning. Our strategy of using dose-volume histograms offers new perspectives to retrospective epidemiological studies.« less

Authors:
; ; ;  [1]; ; ;  [2];  [3];  [2];  [1];  [1]
  1. Radiation Epidemiology Group, Center for Research in Epidemiology and Population Health, Institut National de la Santé et de la Recherche Médicale, UMR 1018, Villejuif (France)
  2. Institut Gustave Roussy, Villejuif (France)
  3. Institut National de la Santé et de la Recherche Médicale UMR 759, Orsay (France)
Publication Date:
OSTI Identifier:
22420516
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 90; Journal Issue: 5; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANATOMY; BONE MARROW; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; LEUKEMIA; PATIENTS; PLANNING; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOTHERAPY; SKELETON; THREE-DIMENSIONAL CALCULATIONS

Citation Formats

Veres, Cristina, Allodji, Rodrigue S., Llanas, Damien, Vu Bezin, Jérémi, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Chavaudra, Jean, Mège, Jean Pierre, Lefkopoulos, Dimitri, Quiniou, Eric, Deutsh, Eric, Institut National de la Santé et de la Recherche Médicale, UMR 1030, Villejuif, Vathaire, Florent de, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Diallo, Ibrahima, Institut Gustave Roussy, Villejuif, and University Paris-Sud XI, Villejuif. Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2014.08.335.
Veres, Cristina, Allodji, Rodrigue S., Llanas, Damien, Vu Bezin, Jérémi, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Chavaudra, Jean, Mège, Jean Pierre, Lefkopoulos, Dimitri, Quiniou, Eric, Deutsh, Eric, Institut National de la Santé et de la Recherche Médicale, UMR 1030, Villejuif, Vathaire, Florent de, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Diallo, Ibrahima, Institut Gustave Roussy, Villejuif, & University Paris-Sud XI, Villejuif. Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms. United States. https://doi.org/10.1016/J.IJROBP.2014.08.335
Veres, Cristina, Allodji, Rodrigue S., Llanas, Damien, Vu Bezin, Jérémi, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Chavaudra, Jean, Mège, Jean Pierre, Lefkopoulos, Dimitri, Quiniou, Eric, Deutsh, Eric, Institut National de la Santé et de la Recherche Médicale, UMR 1030, Villejuif, Vathaire, Florent de, Institut Gustave Roussy, Villejuif, University Paris-Sud XI, Villejuif, Diallo, Ibrahima, Institut Gustave Roussy, Villejuif, and University Paris-Sud XI, Villejuif. 2014. "Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms". United States. https://doi.org/10.1016/J.IJROBP.2014.08.335.
@article{osti_22420516,
title = {Retrospective Reconstructions of Active Bone Marrow Dose-Volume Histograms},
author = {Veres, Cristina and Allodji, Rodrigue S. and Llanas, Damien and Vu Bezin, Jérémi and Institut Gustave Roussy, Villejuif and University Paris-Sud XI, Villejuif and Chavaudra, Jean and Mège, Jean Pierre and Lefkopoulos, Dimitri and Quiniou, Eric and Deutsh, Eric and Institut National de la Santé et de la Recherche Médicale, UMR 1030, Villejuif and Vathaire, Florent de and Institut Gustave Roussy, Villejuif and University Paris-Sud XI, Villejuif and Diallo, Ibrahima and Institut Gustave Roussy, Villejuif and University Paris-Sud XI, Villejuif},
abstractNote = {Purpose: To present a method for calculating dose-volume histograms (DVH's) to the active bone marrow (ABM) of patients who had undergone radiation therapy (RT) and subsequently developed leukemia. Methods and Materials: The study focuses on 15 patients treated between 1961 and 1996. Whole-body RT planning computed tomographic (CT) data were not available. We therefore generated representative whole-body CTs similar to patient anatomy. In addition, we developed a method enabling us to obtain information on the density distribution of ABM all over the skeleton. Dose could then be calculated in a series of points distributed all over the skeleton in such a way that their local density reflected age-specific data for ABM distribution. Dose to particular regions and dose-volume histograms of the entire ABM were estimated for all patients. Results: Depending on patient age, the total number of dose calculation points generated ranged from 1,190,970 to 4,108,524. The average dose to ABM ranged from 0.3 to 16.4 Gy. Dose-volume histograms analysis showed that the median doses (D{sub 50%}) ranged from 0.06 to 12.8 Gy. We also evaluated the inhomogeneity of individual patient ABM dose distribution according to clinical situation. It was evident that the coefficient of variation of the dose for the whole ABM ranged from 1.0 to 5.7, which means that the standard deviation could be more than 5 times higher than the mean. Conclusions: For patients with available long-term follow-up data, our method provides reconstruction of dose-volume data comparable to detailed dose calculations, which have become standard in modern CT-based 3-dimensional RT planning. Our strategy of using dose-volume histograms offers new perspectives to retrospective epidemiological studies.},
doi = {10.1016/J.IJROBP.2014.08.335},
url = {https://www.osti.gov/biblio/22420516}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 90,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 2014},
month = {Mon Dec 01 00:00:00 EST 2014}
}