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Title: Hypofractionated IMRT of the Prostate Bed After Radical Prostatectomy: Acute Toxicity in the PRIAMOS-1 Trial

Abstract

Purpose: Hypofractionated radiation therapy as primary treatment for prostate cancer is currently being investigated in large phase 3 trials. However, there are few data on postoperative hypofractionation. The Radiation therapy for the Prostate Bed With or Without the Pelvic Lymph Nodes (PRIAMOS 1) trial was initiated as a prospective phase 2 trial to assess treatment safety and toxicity of a hypofractionated intensity modulated radiation therapy (IMRT) of the prostate bed. Methods and Materials: From February to September 2012, 40 patients with indications for adjuvant or salvage radiation therapy were enrolled. One patient dropped out before treatment. Patients received 54 Gy in 18 fractions to the prostate bed with IMRT and daily image guidance. Gastrointestinal (GI) and genitourinary (GU) toxicities (according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0) were recorded weekly during treatment and 10 weeks after radiation therapy. Results: Overall acute toxicity was favorable, with no recorded adverse events grade ≥3. Acute GI toxicity rates were 56.4% (grade 1) and 17.9% (grade 2). Acute GU toxicity was recorded in 35.9% of patients (maximum grade 1). Urinary stress incontinence was not influenced by radiation therapy. The incidence of grade 1 urinary urge incontinence increased from 2.6% before to 23.1%more » 10 weeks after therapy, but grade 2 urge incontinence remained unchanged. Conclusions: Postoperative hypofractionated IMRT of the prostate bed is tolerated well, with no severe acute side effects.« less

Authors:
 [1]; ;  [1];  [1];  [1];  [2];  [1];  [1]
  1. Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg (Germany)
  2. Department of Biostatistics, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg (Germany)
Publication Date:
OSTI Identifier:
22420483
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 90; Journal Issue: 4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FRACTIONATED IRRADIATION; LYMPH NODES; NEOPLASMS; PATIENTS; PROSTATE; RADIOTHERAPY; SIDE EFFECTS; TOXICITY

Citation Formats

Katayama, Sonja, Striecker, Thorbjoern, Kessel, Kerstin, Sterzing, Florian, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Habl, Gregor, Edler, Lutz, Debus, Juergen, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, and Herfarth, Klaus. Hypofractionated IMRT of the Prostate Bed After Radical Prostatectomy: Acute Toxicity in the PRIAMOS-1 Trial. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2014.07.015.
Katayama, Sonja, Striecker, Thorbjoern, Kessel, Kerstin, Sterzing, Florian, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Habl, Gregor, Edler, Lutz, Debus, Juergen, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, & Herfarth, Klaus. Hypofractionated IMRT of the Prostate Bed After Radical Prostatectomy: Acute Toxicity in the PRIAMOS-1 Trial. United States. https://doi.org/10.1016/J.IJROBP.2014.07.015
Katayama, Sonja, Striecker, Thorbjoern, Kessel, Kerstin, Sterzing, Florian, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Habl, Gregor, Edler, Lutz, Debus, Juergen, Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, and Herfarth, Klaus. 2014. "Hypofractionated IMRT of the Prostate Bed After Radical Prostatectomy: Acute Toxicity in the PRIAMOS-1 Trial". United States. https://doi.org/10.1016/J.IJROBP.2014.07.015.
@article{osti_22420483,
title = {Hypofractionated IMRT of the Prostate Bed After Radical Prostatectomy: Acute Toxicity in the PRIAMOS-1 Trial},
author = {Katayama, Sonja and Striecker, Thorbjoern and Kessel, Kerstin and Sterzing, Florian and Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg and Habl, Gregor and Edler, Lutz and Debus, Juergen and Department of Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg and Herfarth, Klaus},
abstractNote = {Purpose: Hypofractionated radiation therapy as primary treatment for prostate cancer is currently being investigated in large phase 3 trials. However, there are few data on postoperative hypofractionation. The Radiation therapy for the Prostate Bed With or Without the Pelvic Lymph Nodes (PRIAMOS 1) trial was initiated as a prospective phase 2 trial to assess treatment safety and toxicity of a hypofractionated intensity modulated radiation therapy (IMRT) of the prostate bed. Methods and Materials: From February to September 2012, 40 patients with indications for adjuvant or salvage radiation therapy were enrolled. One patient dropped out before treatment. Patients received 54 Gy in 18 fractions to the prostate bed with IMRT and daily image guidance. Gastrointestinal (GI) and genitourinary (GU) toxicities (according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0) were recorded weekly during treatment and 10 weeks after radiation therapy. Results: Overall acute toxicity was favorable, with no recorded adverse events grade ≥3. Acute GI toxicity rates were 56.4% (grade 1) and 17.9% (grade 2). Acute GU toxicity was recorded in 35.9% of patients (maximum grade 1). Urinary stress incontinence was not influenced by radiation therapy. The incidence of grade 1 urinary urge incontinence increased from 2.6% before to 23.1% 10 weeks after therapy, but grade 2 urge incontinence remained unchanged. Conclusions: Postoperative hypofractionated IMRT of the prostate bed is tolerated well, with no severe acute side effects.},
doi = {10.1016/J.IJROBP.2014.07.015},
url = {https://www.osti.gov/biblio/22420483}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 90,
place = {United States},
year = {Sat Nov 15 00:00:00 EST 2014},
month = {Sat Nov 15 00:00:00 EST 2014}
}