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Title: Impact of Cardiovascular Counseling and Screening in Hodgkin Lymphoma Survivors

Purpose: Cardiovascular disease (CVD) is the most common nonmalignant cause of death in Hodgkin lymphoma (HL) survivors, especially after mediastinal irradiation. The role of screening for CVD in HL survivors is unclear, but confrontation with risks of CVD may have a negative influence on health-related quality of life (HRQL). As part of a phase 2 screening study using computed tomography angiography (CTA) among HL survivors, an HRQL analysis was done to evaluate the emotional and practical burden and perceived benefits of screening and the effect of CVD-specific counseling on patient satisfaction. Methods and Materials: Patients who participated in the screening study also took part in the HRQL study. The impact of undergoing screening was evaluated with a 9-item questionnaire, and impact on HRQL with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire C30, version 3.0. The effect of counseling of CVD on perceived provision of information was evaluated with EORTC INFO-25. All questionnaires were completed at baseline and after screening. Results: Baseline questionnaires were received from 48 participants, and 43 completed questionnaires after screening. Mean age was 47 years, and mean time since diagnosis was 21 years. Of the total, 93% of subjects were contentmore » with participating, and 80% did not find the emphasis placed on late effects burdensome, although screening did have a small impact on social functioning and global quality of life. Perceived information on disease, medical tests, and treatment increased significantly after screening (P<.01). Differences were clinically relevant. There were no differences in perceived information between patients with and without screen-detected CVD. Conclusions: Screening was evaluated favorably, whether CTA showed abnormalities or not. Extensive counseling resulted in substantially increased provision of information and improved information satisfaction. Screening by means of CTA and subsequent cardiac intervention was highly valued, and the benefits were felt to outweigh the emotional and practical burden.« less
Authors:
 [1] ;  [1] ;  [2] ;  [3] ;  [2] ;  [4] ;  [5] ;  [6] ;  [2] ;  [7] ;  [3] ;  [1]
  1. Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands)
  2. Department of Cardiology, Leiden University Medical Center, Leiden (Netherlands)
  3. (Netherlands)
  4. Department of Hematology, Leiden University Medical Center, Leiden (Netherlands)
  5. Department of Medical Statistics and Bio-informatics, Leiden University Medical Center, Leiden (Netherlands)
  6. Department of Radiology, Leiden University Medical Center, Leiden (Netherlands)
  7. Research Department Comprehensive Cancer Center South, Eindhoven (Netherlands)
Publication Date:
OSTI Identifier:
22420422
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 90; Journal Issue: 1; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; CARDIOVASCULAR DISEASES; COMPUTERIZED TOMOGRAPHY; DIAGNOSIS; HAZARDS; LYMPHOMAS; PATIENTS; SCREENING; STANDARD OF LIVING