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Title: A simple and rapid method for high-resolution visualization of single-ion tracks

Prompt determination of spatial points of single-ion tracks plays a key role in high-energy particle induced-cancer therapy and gene/plant mutations. In this study, a simple method for the high-resolution visualization of single-ion tracks without etching was developed through the use of polyacrylic acid (PAA)-N, N’-methylene bisacrylamide (MBAAm) blend films. One of the steps of the proposed method includes exposure of the irradiated films to water vapor for several minutes. Water vapor was found to promote the cross-linking reaction of PAA and MBAAm to form a bulky cross-linked structure; the ion-track scars were detectable at a nanometer scale by atomic force microscopy. This study demonstrated that each scar is easily distinguishable, and the amount of generated radicals of the ion tracks can be estimated by measuring the height of the scars, even in highly dense ion tracks. This method is suitable for the visualization of the penumbra region in a single-ion track with a high spatial resolution of 50 nm, which is sufficiently small to confirm that a single ion hits a cell nucleus with a size ranging between 5 and 20 μm.
Authors:
 [1] ;  [2] ; ; ;  [1] ;  [3] ;  [4]
  1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka 565-0871 (Japan)
  2. (Japan)
  3. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi 980-8577 (Japan)
  4. Japan Atomic Energy Agency, Takasaki Advanced Radiation Research Institute, Gunma, Gunma 370-1292 (Japan)
Publication Date:
OSTI Identifier:
22420167
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Advances; Journal Volume: 4; Journal Issue: 11; Other Information: (c) 2014 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES; ATOMIC FORCE MICROSCOPY; CELL NUCLEI; CROSS-LINKING; IONS; IRRADIATION; MUTATIONS; NEOPLASMS; PARTICLE TRACKS; PARTICLES; PLANTS; RADICALS; SPATIAL RESOLUTION; THERAPY; WATER VAPOR