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Title: Fluctuating hydrodynamics of multicomponent membranes with embedded proteins

A simulation method for the dynamics of inhomogeneous lipid bilayer membranes is presented. The membrane is treated using stochastic Saffman-Delbrück hydrodynamics, coupled to a phase-field description of lipid composition and discrete membrane proteins. Multiple applications are considered to validate and parameterize the model. The dynamics of membrane composition fluctuations above the critical point and phase separation dynamics below the critical point are studied in some detail, including the effects of adding proteins to the mixture.
Authors:
 [1] ;  [2] ;  [3] ;  [2]
  1. Department of Physics and Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093 (United States)
  2. (United States)
  3. Department of Physics, University of California, Santa Barbara, Santa Barbara, California 93106 (United States)
Publication Date:
OSTI Identifier:
22419813
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Chemical Physics; Journal Volume: 141; Journal Issue: 7; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; FLUCTUATIONS; HYDRODYNAMICS; LIPIDS; MEMBRANE PROTEINS; MEMBRANES; MIXTURES; SIMULATION